Effect of stress on methamphetamine intoxication- involvement of stress protein

在本研究中，我们评估了应激对小鼠甲基苯丙胺中毒的影响。小鼠注射30 mg/kg / p（急性组）或10 mg/kg / p（慢性组），每周3次。组织学结果表明，在应激条件下，急性和慢性给药时，甲基苯丙胺对心肌组织的有害作用更大。热休克蛋白（Hsps）在急性期起关键作用，而许多基因，包括抗氧化、抗凋亡基因在慢性期起重要作用。我们获得了糖皮质激素受体（GR）基因多态性对心脏损伤和尿样中8-OHdG的显著影响。在压力下，脑下垂体也受到冰毒的影响。现在，我们正在研究甲基安非他明和/或应激对骨矿物质密度和神经细胞反应的影响。

In the present study, we assessed the effects of stress on intoxication due to methamphetamine (METH) in mice. Mice were injected with 30 mg/kg i.p. (the acute study) or 10 mg/kg i.p three times per week (the chronic study). The histological findings indicated that METH induced more deleterious effects in the myocardial tissues during acute and chronic administrations when under stress conditions. Heat shock proteins (Hsps) played a critical role in the acute phase, while numerous genes, including anti-oxidant, anti-apoptotic genes played significant roles in the chronic phase. We obtained a significant impact of glucocorticoid receptor (GR) gene polymorphism on cardiac injury and 8-OHdG in urine samples. Pituitary glands were also affected by METH under stress. Now, we are investigating the effect of METH and/or stress on bone mineral density and neuronal cell reactions.