Circulating tumor cell-based tailor-made therapy for hepatocellular carcinoma

基于循环肿瘤细胞的肝细胞癌定制疗法

• 批准号: 22590736
• 负责人: NAKAMURA Shinichiro
• 金额: $ 2.83万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590736/
• 关键词: テロメスキャン; 肝細胞癌; circulating tumor cell; h TERT; ソラフェニブ

We detected telomerase-positive cells in the peripheral blood of hepatocellular carcinoma using a new method “TelomeScan”. We confirmed that most of the cells we detected were circulating tumor cells, which was a promising marker of metastasis. Interestingly, we detected the cells even in early stages, indicating another factor is needed to form metastatic lesions. We could not completely overcome the problems of false-positive and false negative and they must be addressed in the future.

我们用一种新的方法“端粒扫描”检测肝癌患者外周血中端粒酶阳性细胞。我们证实，我们检测到的大多数细胞是循环肿瘤细胞，这是一个有希望的转移标志物。有趣的是，我们甚至在早期阶段就检测到了这些细胞，这表明形成转移性病变还需要另一个因素。我们无法完全克服假阳性和假阴性的问题，今后必须加以解决。