Model animals by nonhuman primate for Alzheimer disease, hyper expression of mutant amyloid precursor protein and formation of senile plaques in the brain

非人类灵长类动物模型动物阿尔茨海默病、突变淀粉样前体蛋白的过度表达和大脑中老年斑的形成

• 批准号: 23300155
• 负责人: NAKAMURA Shinichiro
• 金额: $ 12.48万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23300155/
• 关键词: アルツハイマー病; アミロイドβ; アデノ随伴ウイルス; カニクイザル; AAVベクター; 霊長類; 疾患モデル; アミロイドβ蛋白

项目成果

Interaction of p24a2 with γ-secretase complex attenuates γ-cleavage of APP

p24a2 与 γ-分泌酶复合物的相互作用减弱 APP 的 γ-裂解

• 发表时间: 2011
• 作者: Nishimura M;Liu L;Hasegawa H
• 通讯作者: Hasegawa H

Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.

• DOI: 10.1002/ana.22343
• 发表时间: 2011-06
• 期刊: ANNALS OF NEUROLOGY
• 影响因子: 11.2
• 作者: Hata, Saori;Fujishige, Sayaka;Araki, Yoichi;Taniguchi, Miyako;Urakami, Katsuya;Peskind, Elaine;Akatsu, Hiroyasu;Araseki, Masahiko;Yamamoto, Kazuo;Martins, Ralph N.;Maeda, Masahiro;Nishimura, Masaki;Levey, Allan;Chung, Kathryn A.;Montine, Thomas;Leverenz, James;Fagan, Anne;Goate, Alison;Bateman, Randall;Holtzman, David M.;Yamamoto, Tohru;Nakaya, Tadashi;Gandy, Sam;Suzuki, Toshiharu
• 通讯作者: Suzuki, Toshiharu

Human Neural Stem Cells Overexpressing Choline Acetyltransferase Restore Cognitive Function of Kainic Acid-Induced Learning and Memory Deficit Animals

• DOI: 10.3727/096368911x586765
• 发表时间: 2012-01-01
• 期刊: CELL TRANSPLANTATION
• 影响因子: 3.3
• 作者: Park, Dongsun;Joo, Seong Soo;Kim, Seung U.
• 通讯作者: Kim, Seung U.

Potent amyloidogenicity and pathogenicity of Aβ43

• DOI: 10.1038/nn.2858
• 发表时间: 2011-08-01
• 期刊: NATURE NEUROSCIENCE
• 影响因子: 25
• 作者: Saito, Takashi;Suemoto, Takahiro;Saido, Takaomi C.
• 通讯作者: Saido, Takaomi C.