Analysis of regulatory T cells and helper T cells in myocarditis and its application to the therapy for inflammatory cardiovascular diseases.

心肌炎中调节性T细胞和辅助性T细胞的分析及其在炎症性心血管疾病治疗中的应用。

• 批准号: 22590805
• 负责人: KODAMA Makoto
• 金额: $ 2.91万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590805/
• 关键词: 内科; 免疫学; 心筋炎; Th17; 実験的自己免疫性心筋炎; Th1 T細胞; Th17 T細胞; 間葉幹細胞; Fucoidan; ヘム; danger signal; 心筋炎後拡張型心筋症; PDE阻害薬; 肥満細胞; curcumin; Th-17; IL-17; IL-23; 間葉系幹細胞; lipocalin-2

Alterations of IL-17-related protein expressions were investigated. The results showed thatIL-17 was expressed more highly than IFN-gamma expressed by Th1 cells in alpha/beta T cells and the peaks of IL-17 related protein expression in the heart were the early phase of EAM. Then we focused on helper T cell differentiation in allogenic FM-MSC administered EAM rats. Administration of FM-MSC improved left ventricular ejection fraction. The percentage of Th1 cells and Th17 cells were significantly reduced by FM-MSC administration. Thus, intravenous administration of allogenic FM-MSCs ameliorates EAM via the suppression of Th1/Th17 immunity.

观察IL-17相关蛋白表达的变化。结果表明，IL-17在α/β T细胞中的表达高于IFN-γ，IL-17相关蛋白在心肌中的表达高峰出现在EAM的早期。然后，我们专注于在同种异体FM-MSC管理EAM大鼠辅助T细胞分化。给予FM-MSC改善了左心室射血分数。Th 1细胞和Th 17细胞的百分比通过FM-MSC施用显著降低。因此，静脉内施用同种异体FM-MSC通过抑制Th 1/Th 17免疫来改善EAM。

项目成果

Experimental autoimmune myocarditis: role of renin angiotensin system

实验性自身免疫性心肌炎：肾素血管紧张素系统的作用

• 发表时间: 2011
• 期刊: Myocarditis. Edited by Daniela Cihakova, InTech - Open Access Publisher
• 作者: Watanabe K;Arumugam S;Thandavarayan AR;Kodama M
• 通讯作者: Kodama M

Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy.

• DOI: 10.1111/j.1582-4934.2012.01526.x
• 发表时间: 2012-09
• 期刊: Journal of cellular and molecular medicine
• 影响因子: 5.3
• 作者: Arumugam S;Thandavarayan RA;Veeraveedu PT;Nakamura T;Arozal W;Sari FR;Giridharan VV;Soetikno V;Palaniyandi SS;Harima M;Suzuki K;Nagata M;Kodama M;Watanabe K
• 通讯作者: Watanabe K

Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis

• DOI: 10.1016/j.yjmcc.2012.06.020
• 发表时间: 2012-09-01
• 期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
• 影响因子: 5
• 作者: Ohshima, Makiko;Yamahara, Kenichi;Ikeda, Tomoaki
• 通讯作者: Ikeda, Tomoaki

Olmesartan, an AT1 antagonist, attenuates oxidative stress, endoplasmic reticulum stress and cardiac inflammatory mediators in rats with heart failure induced by xperimental autoimmune myocarditis

AT1 拮抗剂奥美沙坦可减轻实验性自身免疫性心肌炎诱发的心力衰竭大鼠的氧化应激、内质网应激和心脏炎症介质

• 发表时间: 2011
• 期刊: Int J Biol Sci
• 影响因子: 9.2
• 作者: Sukumaran V;Watanabe K;Veeraveedu TP;Gurusamy N;Ma M;Yamaguchi K;Suzuki K;Kodama M;Aizawa Y
• 通讯作者: Aizawa Y

Telmisartan ameliorates experimental autoimmune myocarditis associated with inhibition of inflammation and oxidative stress.

替米沙坦可改善与抑制炎症和氧化应激相关的实验性自身免疫性心肌炎。

• 发表时间: 2011
• 期刊: European Journal of Pharmacology. 652
• 作者: Vijayakumar S;K Watanabe;et al
• 通讯作者: et al