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Analysis of regulatory T cells and helper T cells in myocarditis and its application to the therapy for inflammatory cardiovascular diseases.

Analysis of regulatory T cells and helper T cells in myocarditis and its application to the therapy for inflammatory cardiovascular diseases.
心肌炎中调节性T细胞和辅助性T细胞的分析及其在炎症性心血管疾病治疗中的应用。
批准号:
22590805
负责人:
KODAMA Makoto
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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英文摘要
Alterations of IL-17-related protein expressions were investigated. The results showed thatIL-17 was expressed more highly than IFN-gamma expressed by Th1 cells in alpha/beta T cells and the peaks of IL-17 related protein expression in the heart were the early phase of EAM. Then we focused on helper T cell differentiation in allogenic FM-MSC administered EAM rats. Administration of FM-MSC improved left ventricular ejection fraction. The percentage of Th1 cells and Th17 cells were significantly reduced by FM-MSC administration. Thus, intravenous administration of allogenic FM-MSCs ameliorates EAM via the suppression of Th1/Th17 immunity.
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Experimental autoimmune myocarditis: role of renin angiotensin system
实验性自身免疫性心肌炎:肾素血管紧张素系统的作用
DOI: --
发表时间: 2011
期刊: Myocarditis. Edited by Daniela Cihakova, InTech - Open Access Publisher
影响因子: --
作者: [Watanabe K, Arumugam S, Thandavarayan AR, Kodama M]
通讯作者: Kodama M
DOI: 10.1111/j.1582-4934.2012.01526.x
发表时间: 2012-09
期刊: Journal of cellular and molecular medicine
影响因子: 5.3
作者: [Arumugam S, Thandavarayan RA, Veeraveedu PT, Nakamura T, Arozal W, Sari FR, Giridharan VV, Soetikno V, Palaniyandi SS, Harima M, Suzuki K, Nagata M, Kodama M, Watanabe K]
通讯作者: Watanabe K
DOI: 10.1016/j.yjmcc.2012.06.020
发表时间: 2012-09-01
期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
影响因子: 5
作者: [Ohshima, Makiko, Yamahara, Kenichi, Ikeda, Tomoaki]
通讯作者: Ikeda, Tomoaki
Olmesartan, an AT1 antagonist, attenuates oxidative stress, endoplasmic reticulum stress and cardiac inflammatory mediators in rats with heart failure induced by xperimental autoimmune myocarditis
AT1 拮抗剂奥美沙坦可减轻实验性自身免疫性心肌炎诱发的心力衰竭大鼠的氧化应激、内质网应激和心脏炎症介质
DOI: --
发表时间: 2011
期刊: Int J Biol Sci
影响因子: 9.2
作者: [Sukumaran V, Watanabe K, Veeraveedu TP, Gurusamy N, Ma M, Yamaguchi K, Suzuki K, Kodama M, Aizawa Y]
通讯作者: Aizawa Y
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