Analysis of regulatory T cells and helper T cells in myocarditis and its application to the therapy for inflammatory cardiovascular diseases.

心肌炎中调节性T细胞和辅助性T细胞的分析及其在炎症性心血管疾病治疗中的应用。

• 批准号: 22590805
• 负责人: KODAMA Makoto
• 金额: $ 2.91万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590805/
• 关键词: 内科; 免疫学; 心筋炎; Th17; 実験的自己免疫性心筋炎; Th1 T細胞; Th17 T細胞; 間葉幹細胞; Fucoidan; ヘム; danger signal; 心筋炎後拡張型心筋症; PDE阻害薬; 肥満細胞; curcumin; Th-17; IL-17; IL-23; 間葉系幹細胞; lipocalin-2

Alterations of IL-17-related protein expressions were investigated. The results showed thatIL-17 was expressed more highly than IFN-gamma expressed by Th1 cells in alpha/beta T cells and the peaks of IL-17 related protein expression in the heart were the early phase of EAM. Then we focused on helper T cell differentiation in allogenic FM-MSC administered EAM rats. Administration of FM-MSC improved left ventricular ejection fraction. The percentage of Th1 cells and Th17 cells were significantly reduced by FM-MSC administration. Thus, intravenous administration of allogenic FM-MSCs ameliorates EAM via the suppression of Th1/Th17 immunity.

研究了IL-17相关蛋白表达的改变。结果表明，与α/βT细胞中Th1细胞表达的IFN-gammA相比，il-17的表达更高，心脏中IL-17相关蛋白表达的峰是EAM的早期阶段。然后，我们专注于同种异体FM-MSC施用的EAM大鼠的辅助T细胞分化。 FM-MSC的给药可改善左心室射血分数。通过FM-MSC给药可显着降低Th1细胞和Th17细胞的百分比。因此，同种异体FM-MSC的静脉内给药可通过抑制Th1/Th17免疫来改善EAM。

项目成果

Inhibition of cardiac oxidative and endoplasmic reticulum stress-mediated apoptosis by curcumin treatment contributes to protection against acute myocarditis

• DOI: 10.3109/10715762.2011.607252
• 发表时间: 2011-10-01
• 期刊: FREE RADICAL RESEARCH
• 影响因子: 3.3
• 作者: Mito, Sayaka;Thandavarayan, Rajarajan A.;Watanabe, Kenichi
• 通讯作者: Watanabe, Kenichi

Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cel responses in experimental autoimmune myocarditis.

同种异体胎膜来源间充质干细胞的系统移植可抑制实验性自身免疫性心肌炎中的 Th1 和 Th17 T 细胞反应。

• 发表时间: 2012
• 期刊: J Mol Cell Cardiol
• 影响因子: 5
• 作者: Sasano T;Terui M;Nakamura T;Sugiyama K;Yagishita A;Tanaka Y;Kawabata M;Hachiya H;Kawara T;HiraoK;Ohshima M
• 通讯作者: Ohshima M

Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis

• DOI: 10.1016/j.yjmcc.2012.06.020
• 发表时间: 2012-09-01
• 期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
• 影响因子: 5
• 作者: Ohshima, Makiko;Yamahara, Kenichi;Ikeda, Tomoaki
• 通讯作者: Ikeda, Tomoaki

Experimental autoimmune myocarditis: role of renin angiotensin system

实验性自身免疫性心肌炎：肾素血管紧张素系统的作用

• 发表时间: 2011
• 期刊: Myocarditis. Edited by Daniela Cihakova, InTech - Open Access Publisher
• 作者: Watanabe K;Arumugam S;Thandavarayan AR;Kodama M
• 通讯作者: Kodama M

Curcumin Ameliorates Cardiac Inflammation in Rats with Autoimmune Myocarditis

• DOI: 10.1248/bpb.34.974
• 发表时间: 2011-07-01
• 期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 2
• 作者: Mrro, Sayaka;Watanabe, Kenichi;Aizawa, Yoshifusa
• 通讯作者: Aizawa, Yoshifusa