Identification of MicroRNAs involved in formation of foam cells that are associated with atherosclerosis-related gene lymphotoxin-alpha

鉴定参与与动脉粥样硬化相关基因淋巴毒素-α相关的泡沫细胞形成的MicroRNA

• 批准号: 22590827
• 负责人: SAKATA Yasuhiko
• 金额: $ 3万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590827/
• 关键词: 分子血管病態学; 心筋梗塞; 高血圧; 遺伝子多型; アンジオテンシン; マクロファージ; 動脈硬化; マイクロRNA; リンホトキシンα

We tried to Identify microRNAs involved in f ormation of foam cells that are associated with atherosclerosis-related gene lymphotoxin-alpha (LTA). However, we found that LTA was unlikely involved in foam cell formation. Thus, we changed our plan and identified microRNAs that are associated with cardiac death in patients who survived acute myocardial infarction, a major cause of death as a result of atherosclerotic diseases.

我们试图鉴定与动脉粥样硬化相关基因淋巴毒素-α(LTA)相关的泡沫细胞形成过程中涉及的microRNAs。然而，我们发现LTA不太可能参与泡沫细胞的形成。因此，我们改变了我们的计划，确定了与急性心肌梗死患者心源性死亡相关的microRNAs，急性心肌梗死是动脉粥样硬化性疾病导致死亡的主要原因。

项目成果

Circulating MicroRNAs as Therepeutic Targets for Cardiac Remodeling and Heart Failure in Patients after Acute Myocardial Infarction.

循环 MicroRNA 作为急性心肌梗死后患者心脏重塑和心力衰竭的治疗靶点。

• 发表时间: 2013
• 作者: Sen Matsumoto;Yasuhiko Sakata;Daisaku Nakatani;Shinichiro Suna;Masaya Usami;Masahiko Hara;Yukio Kawahara;Toru Oka;Seiji Takashima;Tatsuya Sasaki;Hiroshi Sato;Shinsuke Nanto;Issei Komuro
• 通讯作者: Issei Komuro

The association of circulating microRNAs with prognosis of patients after acute myocardial infarction

循环microRNA与急性心肌梗死患者预后的关系

• 发表时间: 2012
• 作者: Yusuke Kurogane;Yoshiyuki Rikitake;et al.;Sen Matsumoto
• 通讯作者: Sen Matsumoto