Evaluation of gene-environment interaction in development of chronic kidney disease and cardio-vascular disease

慢性肾脏病和心血管疾病发生过程中基因-环境相互作用的评价

• 批准号: 22590888
• 负责人: HAYASHI Mutsuharu
• 金额: $ 2.83万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590888/
• 关键词: 腎臓学; 一塩基多形(SNP); 環境因子; メタボリック症候群; 糖尿病(DM); 慢性腎臓病(CKD); CKD; SNP; バイオインフォマティクス; CVD; 遺伝子環境相互作用

We acquired the company medical examination data for the past several years more than 50,000, medical careinformation including the environmental parameter (smoking, meal taste, exercise customs) at the same time to perform DNA extraction, the SNPs analysis of approximately 1,200 people with an agreement, the cooperation of a company and the employee. We developed an SNP tip for metabolic syndrome and diabetes and extracted disease group and a control group and performed SNP analysis. Using bioinformatics software of the new development, I performed SNP and a blood test, combination of environmental parameter analysis and identified a new combination about a risk about metabolic syndrome, diabetes onset and progression.

在过去的几年中，我们获得了公司的医学检查数据，超过50,000个医疗信息，包括环境参数（吸烟，进餐味，运动习俗），同时进行DNA提取，对大约1,200人达成协议的人的SNP分析，公司的合作和员工。我们开发了一种用于代谢综合征和糖尿病的SNP尖端，以及提取的疾病组以及对照组并进行了SNP分析。使用新开发的生物信息学软件，我进行了SNP和血液测试，环境参数分析的组合，并确定了有关代谢综合征，糖尿病发作和进展的新组合。

项目成果

Impact of Indoxyl Sulfate on the Progression of Endothelial Dysfunction and Atherosclerosis in Chronic Kidney Disease Patients

硫酸吲哚酚对慢性肾病患者内皮功能障碍和动脉粥样硬化进展的影响

• 发表时间: 2013
• 作者: Mutsuharu Hayashi;Hideki Ishii;Daiji Yoshikawa;Akihiro Hirashiki;Takahiro Okumura;Toyoaki Murohara
• 通讯作者: Toyoaki Murohara

Validation of the equations for estimating daily sodium excretion from spot urine in patients with chronic kidney disease

• DOI: 10.1007/s10157-011-0523-0
• 发表时间: 2011-12-01
• 期刊: CLINICAL AND EXPERIMENTAL NEPHROLOGY
• 影响因子: 2.3
• 作者: Imai, Enyu;Yasuda, Yoshinari;Matsuo, Seiichi
• 通讯作者: Matsuo, Seiichi

Effects of carperitide on contrast-induced acute kidney injury with a minimum volume of contrast in chronic kidney disease patients.

• DOI: 10.1159/000345483
• 发表时间: 2012-01
• 期刊: Nephron extra
• 作者: Okumura N;Hayashi M;Imai E;Ishii H;Yoshikawa D;Yasuda Y;Goto M;Matsuo S;Oiso Y;Murohara T
• 通讯作者: Murohara T

Brain Natriuretic Peptide as a Nobel Marker of Salt-sensitivity in Chronic Kidney Disease Patients without Cardiac Dysfunction

脑利钠肽作为无心脏功能障碍的慢性肾病患者盐敏感性的诺贝尔标志物

• 发表时间: 2013
• 作者: Mutsuharu Hayashi;Hideki Ishii;Daiji Yoshikawa;Akihiro Hirashiki;Takahiro Okumura;Toyoaki Murohara
• 通讯作者: Toyoaki Murohara

Brain Natriuretic Peptide as a Nobel Marker of Salt-sensitivity in Chronic Kidney Disease Patients without Cardiac Dysfunction

脑利钠肽作为无心脏功能障碍的慢性肾病患者盐敏感性的诺贝尔标志物

• 发表时间: 2013
• 作者: 久米真司;宇津 貴;木村友則;Ying Zhang;Mutsuharu Hayashi
• 通讯作者: Mutsuharu Hayashi