Evaluation of gene-environment interaction in development of chronic kidney disease and cardio-vascular disease

慢性肾脏病和心血管疾病发生过程中基因-环境相互作用的评价

• 批准号: 22590888
• 负责人: HAYASHI Mutsuharu
• 金额: $ 2.83万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590888/
• 关键词: 腎臓学; 一塩基多形(SNP); 環境因子; メタボリック症候群; 糖尿病(DM); 慢性腎臓病(CKD); CKD; SNP; バイオインフォマティクス; CVD; 遺伝子環境相互作用

We acquired the company medical examination data for the past several years more than 50,000, medical careinformation including the environmental parameter (smoking, meal taste, exercise customs) at the same time to perform DNA extraction, the SNPs analysis of approximately 1,200 people with an agreement, the cooperation of a company and the employee. We developed an SNP tip for metabolic syndrome and diabetes and extracted disease group and a control group and performed SNP analysis. Using bioinformatics software of the new development, I performed SNP and a blood test, combination of environmental parameter analysis and identified a new combination about a risk about metabolic syndrome, diabetes onset and progression.

我们获得了公司过去几年的体检数据超过50，000份，医疗保健信息包括环境参数（吸烟，饮食口味，运动习惯），同时进行DNA提取，SNPs分析约1，200人与协议，公司和员工的合作。我们开发了代谢综合征和糖尿病的SNP提示，并提取了疾病组和对照组，并进行了SNP分析。利用新开发的生物信息学软件，进行SNP和血液检测，结合环境参数分析，确定了一个关于代谢综合征、糖尿病发病和进展风险的新组合。

项目成果

Effects of carperitide on contrast-induced acute kidney injury with a minimum volume of contrast in chronic kidney disease patients.

• DOI: 10.1159/000345483
• 发表时间: 2012-01
• 期刊: Nephron extra
• 作者: Okumura N;Hayashi M;Imai E;Ishii H;Yoshikawa D;Yasuda Y;Goto M;Matsuo S;Oiso Y;Murohara T
• 通讯作者: Murohara T

Validation of the equations for estimating daily sodium excretion from spot urine in patients with chronic kidney disease

• DOI: 10.1007/s10157-011-0523-0
• 发表时间: 2011-12-01
• 期刊: CLINICAL AND EXPERIMENTAL NEPHROLOGY
• 影响因子: 2.3
• 作者: Imai, Enyu;Yasuda, Yoshinari;Matsuo, Seiichi
• 通讯作者: Matsuo, Seiichi

Impact of Indoxyl Sulfate on the Progression of Endothelial Dysfunction and Atherosclerosis in Chronic Kidney Disease Patients

硫酸吲哚酚对慢性肾病患者内皮功能障碍和动脉粥样硬化进展的影响

• 发表时间: 2013
• 作者: Mutsuharu Hayashi;Hideki Ishii;Daiji Yoshikawa;Akihiro Hirashiki;Takahiro Okumura;Toyoaki Murohara
• 通讯作者: Toyoaki Murohara

Platelet activation and induction of tissue factor in acute and chronic atrial fibrillation: Involvement of mononuclear cell-platelet interaction

• DOI: 10.1016/j.thromres.2011.07.013
• 发表时间: 2011-12-01
• 期刊: THROMBOSIS RESEARCH
• 影响因子: 7.5
• 作者: Hayashi, Mutsuharu;Takeshita, Kyosuke;Murohara, Toyoaki
• 通讯作者: Murohara, Toyoaki

Brain Natriuretic Peptide as a Novel Marker of Salt-sensitivity in Chronic Kidney Disease Patients without Cardiac Dysfunction

脑利钠肽作为无心脏功能障碍的慢性肾病患者盐敏感性的新标志物

• 发表时间: 2012
• 作者: Mutsuharu Hayashi;Yoshinari Yasuda;Hideki Ishii;Daiji Yoshikawa;Toyoaki Murohara
• 通讯作者: Toyoaki Murohara