The function and mechanism of Transgelin that expresses in injured glomerular epithelial cells.
The function and mechanism of Transgelin that expresses in injured glomerular epithelial cells.
批准号:
22590882
负责人:
SAKATSUME Minoru
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Transgelin has been revealed to express in injured glomerukar epithelial cells and interstitial cells of both rat and human. It is located in the area of foot process effacement and represents the podocyte injury in glomeruli. The expression is specific for renal cell injury. The extent of its positivity in glomerular or tubulointerstitial area is the determinant of the amount of proteinuria or the deterioration of creatinine clearance (Ccr), respectively. The mechanism of its expression largely depends on the signal transduction of TGFβ.
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腎障害の検出方法
如何检测肾脏损伤
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[]
通讯作者:
Injured kidney cells express SM22a(transgelin) :Unique features distinct from a-smooth muscle actin(aSIVIA).
受损的肾细胞表达 SM22a(转凝胶蛋白):与 a-平滑肌肌动蛋白 (aSIVIA) 不同的独特特征。
DOI:
--
发表时间:
2011
期刊:
Nephrology
影响因子:
2.5
作者:
[Sakamaki Y, et al]
通讯作者:
et al
ヒトおよびラット腎疾患における腎細胞障害分子6M22α発現の病理学的意義
肾细胞毒分子6M22α表达在人和大鼠肾脏疾病中的病理意义
DOI:
--
发表时间:
期刊:
新潟医学会雑誌
影响因子:
--
作者:
[Chiang, et al., Fadini GP, 王興智]
通讯作者:
王興智
Redox State of Urinary Albumin in Patients with IgA Nephropathy
IgA肾病患者尿白蛋白的氧化还原状态
DOI:
--
发表时间:
2011
期刊:
Rinsho Byori
影响因子:
--
作者:
[Nakayama A, Odake J, Kanke A, Sakatsume M, Kasama T, Shiba K]
通讯作者:
Shiba K
Expression of SM22a(Transgelin)in Glomerular and Interstitial Renal Injury.
SM22a(Transgelin)在肾小球和间质性肾损伤中的表达。
DOI:
--
发表时间:
2011
期刊:
Nephron Experimental Nephrology
影响因子:
--
作者:
[Inomata S, et al]
通讯作者:
et al
共 10 条
The investigation of new functional molecules that express during the development of glomerulonephritis for the clinical application.
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批准号:19590943
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
-
财政年份:2007
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负责人:SAKATSUME Minoru
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依托单位: