Effects of renal tissue-specific NFkB blockade on aging kidneys
Effects of renal tissue-specific NFkB blockade on aging kidneys
肾组织特异性 NFkB 阻断对衰老肾脏的影响
批准号：
22590897
负责人：
OKADA Hirokazu
金额：
$1.58万
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2012
中文摘要
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英文摘要
We generated genetically-modified mice, gGT.Cre:IkBdN mice, in which the NFkB pathway is blocked exclusively in tubular epithelium. In the kidney of wild-type mice at 20 month-old, peritubular fibrosis was observed compared to those at 3 moth-old, which seemed to be an age-related, histological change. In contrast, peritubular fibrosis was significantly enhanced in the kidney of gGT.Cre:IkBdN mice at 20 month-old. Therefore, long-term blockade of NFkB pathway in tubular epithelium was supposed to accelerate renal fibrogenesis.
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会议论文
Targeted Inhibition of NF-kB Activation in Tubular Epithelia Protects Mice Against Renal Fibrogenesis Following NTN
靶向抑制肾小管上皮细胞中 NF-kB 的激活可保护小鼠 NTN 后免受肾纤维化
靶向抑制肾小管上皮细胞中 NF-kB 的激活可保护小鼠 NTN 后免受肾纤维化
DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
[T.Inoue, 他]
通讯作者：
他
DOI：
10.1016/j.cell.2013.03.020
发表时间：
2013-04-11
期刊：
Cell
影响因子：
64.5
作者：
[Lujambio A, Akkari L, Simon J, Grace D, Tschaharganeh DF, Bolden JE, Zhao Z, Thapar V, Joyce JA, Krizhanovsky V, Lowe SW]
通讯作者：
Lowe SW
Effect of fibroblast-specific suicidal-gene against rapidly progressive glomerulonephritis
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批准号：13671127
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$1.86万
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财政年份：2001
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负责人：OKADA Hirokazu
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依托单位：
海外基金