Role of AT4/IRAP extracted by systemic transcriptome analysis for hypertensive and diabetic renal tissue

通过系统的转录组分析和RT-PCR，我们已经确定AT4/IRAP是高血压/糖尿病的特异性基因。这种蛋白质被认为与肾素-血管紧张素系统和胰岛素信号转导有关。建立了酶联免疫吸附试验检测系统。因此，我们首次提出AT4/IRAP可能参与生活方式相关疾病的病理生理学。

We have identified AT4/IRAP as a hypertension/diabetes-specific gene through systemic transcriptome analysis followed by RT-PCR. This protein is thought to be involved in the renin-angiotensin system and insulin signal transduction. We have established a measurement system by ELISA. Thereby for the first time we could suggest the possibility that AT4/IRAP might be involved in the pathophysiology of life-style related diseases.