Expression of MAK-V/Hunk in renal distal tubules and its possible involvement in proliferative suppression
Expression of MAK-V/Hunk in renal distal tubules and its possible involvement in proliferative suppression
批准号:
22590913
负责人:
KANAOKA Tomohiko
金额:
$1.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
点击翻译按钮获取中文摘要
英文摘要
We demonstrated that high-salt loading suppressed renal MAK-V/Hunk mRNA levels in wild-type mice. To analyze the possible renal function of HUNK/MAK-V, we generated MAK-V/Hunk transgenic mice. The MAK-V/Hunk transgenic mice exhibited the suppression of high salt loading-mediated hypertension compared with wild-type mice. We also showed an altered renal distribution of HUNK/MAK-V inthe diseased human kidney. Collectively, these results indicate a critical role of renal MAK-V/Hunk in the renal sodium handling and blood pressure regulation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1161/hypertensionaha.111.175208
发表时间:
2012-03
期刊:
Hypertension
影响因子:
8.3
作者:
[N. Yasuda;H. Akazawa;K. Ito;I. Shimizu;Yoko Kudo-Sakamoto;Chizuru Yabumoto;M. Yano;R. Yamamoto;Yukako Ozasa;T. Minamino;A. Naito;T. Oka;I. Shiojima;K. Tamura;S. Umemura;P. Paradis;M. Nemer;I. Komuro]
通讯作者:
N. Yasuda;H. Akazawa;K. Ito;I. Shimizu;Yoko Kudo-Sakamoto;Chizuru Yabumoto;M. Yano;R. Yamamoto;Yukako Ozasa;T. Minamino;A. Naito;T. Oka;I. Shiojima;K. Tamura;S. Umemura;P. Paradis;M. Nemer;I. Komuro
Relationship of ambulatory blood pressure and heart rate profile with renal function parameters in hypertensive patients with chronic kidney disease
高血压合并慢性肾脏病患者动态血压、心率曲线与肾功能参数的关系
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kanaoka T, Tamura K, et al]
通讯作者:
et al
Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice
血管紧张素 II 输注小鼠中血管紧张素 II 1 型受体结合分子的肾内抑制
DOI:
--
发表时间:
2010
期刊:
Am J Physiol Renal Physiol
影响因子:
--
作者:
[Wakui H, Tamura K, Matsuda M, Bai Y, Dejima T, Shigenaga A, Masuda S, Azuma K, Maeda A, Hirose T, Ishigami T, Toya Y, Yabana M, Minamisawa S, Umemura S.]
通讯作者:
Umemura S.
Angiotensin II Type 1 Receptor Blocker Olmesartan Preferentially Improves Nocturnal Hypertension and Proteinuria in Chronic Kidney Disease
血管紧张素 II 1 型受体阻滞剂奥美沙坦优先改善慢性肾脏病的夜间高血压和蛋白尿
DOI:
--
发表时间:
2013
期刊:
Hypertension Research
影响因子:
5.4
作者:
[Yanagi M, Kanaoka T, et al.]
通讯作者:
et al.
DOI:
10.1111/j.1751-7176.2012.00640.x
发表时间:
2012-08-01
期刊:
JOURNAL OF CLINICAL HYPERTENSION
影响因子:
2.8
作者:
[Kanaoka, Tomohiko, Tamura, Kouichi, Umemura, Satoshi]
通讯作者:
Umemura, Satoshi
共 22 条
A pathophysiological significance of a novel angiogenesis factor in diabetic kidney disease and chronic kidney disease
-
批准号:19K08730
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2019
-
负责人:KANAOKA Tomohiko
-
依托单位:
Receptor-based modulation of cardiovascular disease in the process of aging
-
批准号:25460906
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.5万
-
财政年份:2013
-
负责人:KANAOKA Tomohiko
-
依托单位:
海外基金