Expression of MAK-V/Hunk in renal distal tubules and its possible involvement in proliferative suppression

MAK-V/Hunk 在肾远曲小管中的表达及其可能参与增殖抑制

• 批准号: 22590913
• 负责人: KANAOKA Tomohiko
• 金额: $ 1.83万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590913/
• 关键词: 遺伝子; 細胞・組織; 発生・文化; 循環器・高血圧; シグナル伝達; 発生・分化; 腎臓・高血圧; 生体分子; 生理活性

We demonstrated that high-salt loading suppressed renal MAK-V/Hunk mRNA levels in wild-type mice. To analyze the possible renal function of HUNK/MAK-V, we generated MAK-V/Hunk transgenic mice. The MAK-V/Hunk transgenic mice exhibited the suppression of high salt loading-mediated hypertension compared with wild-type mice. We also showed an altered renal distribution of HUNK/MAK-V inthe diseased human kidney. Collectively, these results indicate a critical role of renal MAK-V/Hunk in the renal sodium handling and blood pressure regulation.

我们证明高盐负荷抑制野生型小鼠肾脏MAK-V/Hunk mRNA水平。为了分析HUNK/MAK-V可能的肾脏功能，我们制造了MAK-V/ HUNK转基因小鼠。与野生型小鼠相比，MAK-V/Hunk转基因小鼠对高盐负荷介导的高血压表现出抑制作用。我们还发现HUNK/MAK-V在患病人肾脏中的分布发生了改变。总之，这些结果表明肾脏MAK-V/Hunk在肾脏钠处理和血压调节中起关键作用。

项目成果

Agonist-Independent Constitutive Activity of Angiotensin II Receptor Promotes Cardiac Remodeling in Mice

• DOI: 10.1161/hypertensionaha.111.175208
• 发表时间: 2012-03
• 期刊: Hypertension
• 影响因子: 8.3
• 作者: N. Yasuda;H. Akazawa;K. Ito;I. Shimizu;Yoko Kudo-Sakamoto;Chizuru Yabumoto;M. Yano;R. Yamamoto;Yukako Ozasa;T. Minamino;A. Naito;T. Oka;I. Shiojima;K. Tamura;S. Umemura;P. Paradis;M. Nemer;I. Komuro

Relationship of ambulatory blood pressure and heart rate profile with renal function parameters in hypertensive patients with chronic kidney disease

高血压合并慢性肾脏病患者动态血压、心率曲线与肾功能参数的关系

• 发表时间: 2012
• 作者: Kanaoka T;Tamura K;et al
• 通讯作者: et al

Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice

血管紧张素 II 输注小鼠中血管紧张素 II 1 型受体结合分子的肾内抑制

• 发表时间: 2010
• 期刊: Am J Physiol Renal Physiol
• 作者: Wakui H;Tamura K;Matsuda M;Bai Y;Dejima T;Shigenaga A;Masuda S;Azuma K;Maeda A;Hirose T;Ishigami T;Toya Y;Yabana M;Minamisawa S;Umemura S.
• 通讯作者: Umemura S.

Angiotensin II Type 1 Receptor Blocker Olmesartan Preferentially Improves Nocturnal Hypertension and Proteinuria in Chronic Kidney Disease

血管紧张素 II 1 型受体阻滞剂奥美沙坦优先改善慢性肾脏病的夜间高血压和蛋白尿

• 发表时间: 2013
• 期刊: Hypertension Research
• 影响因子: 5.4
• 作者: Yanagi M;Kanaoka T;et al.
• 通讯作者: et al.

Effects of Aliskiren-Based Therapy on Ambulatory Blood Pressure Profile, Central Hemodynamics, and Arterial Stiffness in Nondiabetic Mild to Moderate Hypertensive Patients

• DOI: 10.1111/j.1751-7176.2012.00640.x
• 发表时间: 2012-08-01
• 期刊: JOURNAL OF CLINICAL HYPERTENSION
• 影响因子: 2.8
• 作者: Kanaoka, Tomohiko;Tamura, Kouichi;Umemura, Satoshi
• 通讯作者: Umemura, Satoshi