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Expression of MAK-V/Hunk in renal distal tubules and its possible involvement in proliferative suppression

Expression of MAK-V/Hunk in renal distal tubules and its possible involvement in proliferative suppression
MAK-V/Hunk 在肾远曲小管中的表达及其可能参与增殖抑制
批准号:
22590913
负责人:
KANAOKA Tomohiko
金额:
$1.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We demonstrated that high-salt loading suppressed renal MAK-V/Hunk mRNA levels in wild-type mice. To analyze the possible renal function of HUNK/MAK-V, we generated MAK-V/Hunk transgenic mice. The MAK-V/Hunk transgenic mice exhibited the suppression of high salt loading-mediated hypertension compared with wild-type mice. We also showed an altered renal distribution of HUNK/MAK-V inthe diseased human kidney. Collectively, these results indicate a critical role of renal MAK-V/Hunk in the renal sodium handling and blood pressure regulation.
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DOI: 10.1161/hypertensionaha.111.175208
发表时间: 2012-03
期刊: Hypertension
影响因子: 8.3
作者: [N. Yasuda;H. Akazawa;K. Ito;I. Shimizu;Yoko Kudo-Sakamoto;Chizuru Yabumoto;M. Yano;R. Yamamoto;Yukako Ozasa;T. Minamino;A. Naito;T. Oka;I. Shiojima;K. Tamura;S. Umemura;P. Paradis;M. Nemer;I. Komuro]
通讯作者: N. Yasuda;H. Akazawa;K. Ito;I. Shimizu;Yoko Kudo-Sakamoto;Chizuru Yabumoto;M. Yano;R. Yamamoto;Yukako Ozasa;T. Minamino;A. Naito;T. Oka;I. Shiojima;K. Tamura;S. Umemura;P. Paradis;M. Nemer;I. Komuro
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kanaoka T, Tamura K, et al]
通讯作者: et al
Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice
血管紧张素 II 输注小鼠中血管紧张素 II 1 型受体结合分子的肾内抑制
DOI: --
发表时间: 2010
期刊: Am J Physiol Renal Physiol
影响因子: --
作者: [Wakui H, Tamura K, Matsuda M, Bai Y, Dejima T, Shigenaga A, Masuda S, Azuma K, Maeda A, Hirose T, Ishigami T, Toya Y, Yabana M, Minamisawa S, Umemura S.]
通讯作者: Umemura S.
Angiotensin II Type 1 Receptor Blocker Olmesartan Preferentially Improves Nocturnal Hypertension and Proteinuria in Chronic Kidney Disease
血管紧张素 II 1 型受体阻滞剂奥美沙坦优先改善慢性肾脏病的夜间高血压和蛋白尿
DOI: --
发表时间: 2013
期刊: Hypertension Research
影响因子: 5.4
作者: [Yanagi M, Kanaoka T, et al.]
通讯作者: et al.
22
    A pathophysiological significance of a novel angiogenesis factor in diabetic kidney disease and chronic kidney disease
    • 批准号:
      19K08730
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2019
    • 负责人:
      KANAOKA Tomohiko
    • 依托单位:
    Receptor-based modulation of cardiovascular disease in the process of aging
    • 批准号:
      25460906
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.5万
    • 财政年份:
      2013
    • 负责人:
      KANAOKA Tomohiko
    • 依托单位:
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