Study on Mechano-Sensing Channel in muscular dystrophic dog

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A number of studies have reported the elevation of the cytosolic Ca2+ concentration in skeletal and cardiac muscles of muscular dystrophy. Chronic elevation of the cytosolic Ca2+ concentration could activate Ca2+-dependent cell signaling cascade and induce cell necrosis. The cellular mechanism for controlling Ca2+ influx in muscular dystrophy, however, is still unknown. The TRP channels form a large family of cation channels that likely function as tetramers in various processes, such as sensory signaling, most of which are permeable for Ca2+, and some also for Mg2+. To determine the relationship between TRP family and muscle degeneration, we analyzed the expression of TRP channel in skeletal and cardiac muscle of Canine models of Duchenne muscular dystrophy.