Roles of KATP channel/insulin signaling in the hypothalamus on the regulation of glucose homeostasis

KATP通道可能通过作为代谢感受器来调节不同细胞类型的细胞兴奋性。尤其是作为体内代谢中心的下丘脑，在胰岛素靶向组织的代谢调节中起着重要的作用。在本研究中，我们发现脂肪组织中的胰岛素信号是由脑KATP通道外源性调节的，KATP通道参与了脑干和下丘脑的几个核团的葡萄糖感受。

KATP channel is suggested to regulate cellular excitability of various cell types by acting as a metabolic sensor. Especially, the channel in the hypothalamus, the metabolic center in the body, plays an important role in metabolic regulation of insulin targeted tissues. In the present study, we found that insulin signaling in the adipose tissues is modulated exogenously by the brain KATP channel and that KATP channel is involved in the glucose sensing in several nuclei in the brain stem as well as the hypothalamus.