Mechanism of browning of white adipocyte and growing of atherosclerotic plaque

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Our findings demonstrate a novel role for PLIN1 expression in adipose tissue metabolism and regulation of obesity and its metabolic complications. Overexpression of PLIN1 in white adipocytes reduces lipid droplet size by decreasing the expression of other lipid droplet proteins like FSP27 and thereby inducing a brown adipose tissue-like phenotype.In the other study, we investigated the relationship between macrophage polarity and the vulnerability of human atherosclerotic plaques and clinical events. Macrophage polarity of atherosclerotic plaques was associated with clinical incidence of ischemic stroke, and unstable plaques defined by ultrasound.