Role of ABCA1/G1 proteon degradation on HDL-mediated anti-atherogenesis

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We demonstrated that ABCA1/G1 was degraded via polyubiquitination in the ubiquitin-proteasome system (UPS). Furthermore, inhibition of the UPS using proteasome inhibitors enhanced both apoA-I- and HDL-mediated cholesterol efflux from macrophages by increasing ABCA1/G1 expressions. Finally, bortezomib, a proteasome inhibitor, promoted overall RCT in vivo in mice. These findings may ultimately provide the basis for a novel therapeutic strategy for atherosclerotic diseases.