Investigation for molecular mechanisms underlying the establishment of "pre"-leukemic stem cells aiming for therapy and prevention of leukemia

研究建立“前”白血病干细胞以治疗和预防白血病的分子机制

• 批准号: 22591054
• 负责人: TSUZUKI Shinobu
• 金额: $ 2.91万
• 依托单位: Aichi Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591054/
• 关键词: 前白血病; 白血病性幹細胞

"Pre"-leukemic stage is crucial for the establishment of leukemia. Elucidation of mechanisms underlying the pre-leukemic stage would pave the way to the development of therapy and preventive measures of leukemia. We have successfully modeled "pre"-leukemic stage of TEL-AML1 leukemia in mice, and thus identified 4 genes essential for the establishment of "pre"-leukemic cells. The 4 genes are also essential for the maintenance of leukemia, providing the rationale for strategy of targeting the genes for therapy and prevention of leukemia.

白血病前期是白血病发生的关键阶段。阐明白血病前期的发病机制将为白血病的治疗和预防措施的发展铺平道路。我们已经成功地在小鼠中建立了TEL-AML 1白血病的“前”白血病阶段的模型，并因此鉴定了建立“前”白血病细胞所必需的4个基因。这4个基因对白血病的维持也是必不可少的，为靶向基因治疗和预防白血病的策略提供了理论基础。

项目成果

TEL(ETV6)-AML1(RUNX1) Initiates Self-renewing Fetal Pro-B Cells in Association with a Transcriptional Program Shared with Embryonic Stem Cells in Mice.

TEL(ETV6)-AML1(RUNX1) 启动胎儿 Pro-B 细胞的自我更新，并与小鼠胚胎干细胞共享的转录程序相关。

• DOI: 10.1002/stem.1277
• 发表时间: 2013
• 期刊: Stem Cells
• 影响因子: 5.2
• 作者: Komatsu S;Miyazawa K;Moriya S;Takase A;Naito M;Inazu M;Kohno N;Itoh M;Tomoda A;Tsuzuki S and Seto M.
• 通讯作者: Tsuzuki S and Seto M.

ERG発現による白血病化

ERG表达引起的白血病

• 发表时间: 2011
• 作者: Harumi Kato;Kazuhito Yamamoto;Masao Seto;Harumi Kato;Kiyoko Yamamoto;加藤春美,山本一仁,瀬戸加大;都築忍,瀬戸加大
• 通讯作者: 都築忍,瀬戸加大

Altered differentiation and enhanced self-renewal activity of B cells by the leukemia-associated TEL(ETV6)-AML1(RUNX1) fusion gene

白血病相关 TEL(ETV6)-AML1(RUNX1) 融合基因改变 B 细胞的分化并增强自我更新活性

• 发表时间: 2011
• 作者: Masaharu Tashima;Masao Seto(他6名;8番目);Masaharu Tashima;加留部謙之輔,中川雅夫,瀬戸加大;加留部謙之輔;加藤春美,山本一仁,瀬戸加大;瀬戸加大;加藤春美;松浦恵子,中田知里,瀬戸加大;成松隆弘,松浦恵子,瀬戸加大;都築忍,瀬戸加大
• 通讯作者: 都築忍,瀬戸加大

Cooperation of altered AML1/RUNX1 with BCR-ABL in inducing blast crisis-like disease of chronic myelogenous leukemia.

改变的 AML1/RUNX1 与 BCR-ABL 协同诱导慢性粒细胞白血病急变样疾病。

• 作者: Inokuchi K;et al;都 築 忍
• 通讯作者: 都 築 忍

Cooperation of altered AML1/RUNX1 with BCR-ABL in inducing blast crisis-like disease of chronic myelogenous leukemia.

改变的 AML1/RUNX1 与 BCR-ABL 协同诱导慢性粒细胞白血病急变样疾病。

• 发表时间: 2012
• 作者: Noji H;Usuki K;Otsuka M;Horiuchi H;Yamamoto T;Takahashi H;Takeishi Y;Shichishima T;都築忍
• 通讯作者: 都築忍