Novel functions and Mechanisms of Coagulation Factor XIII/13 in the Platelet/Fibrin Clot Retraction Reaction
Novel functions and Mechanisms of Coagulation Factor XIII/13 in the Platelet/Fibrin Clot Retraction Reaction
批准号:
22591058
负责人:
ICHINOSE Akitada
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
The results of our 3-years studies strongly suggested that intracellular factor XIII (FXIII)A-subunit (FXIII-A) plays a role(s) in the proliferation and differentiation of monocytes/macrophages and megakaryocytes/platelets. It was clearly demonstrated thatextracellular FXIII-A activated the platelet signal transduction system(s) and inducedplatelet/fibrin clot retraction via biding to glycoprotein IIb/IIIa (Submitted). However, we could not conclude whether or not intracellular FXIII-A was essential in this reaction.
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凝固XIII因子Aサブユニットに対するモノクローナル抗体のエピトープ探索.
针对凝血因子 XIII A 亚基的单克隆抗体的表位搜索。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Murakami, Y., N. Inoue, T. Shichishima, R. Ohta, H. Noji, Y. Maeda, J. Nishimura, Y. Kanakura and T. Kinoshita, 加藤光次, 笠原 浩二, 福島卓也 森内幸美 吉田真一郎 糸永英弘 田口潤 宮崎泰司, 尾崎 司]
通讯作者:
尾崎 司
Acquired hemophilia-like disease due to anti-Factor XIII autoantibodies, the most under-diagnosed bleeding disorder.
由抗因子 XIII 自身抗体引起的获得性血友病样疾病,这是最容易被诊断不足的出血性疾病。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kameoka J, Takahashi N, Noji H, Murai K, Tajima K, Kameoka Y, Sato S, Shichishima T, Ishida Y, Harigae H, Sawada K, Ichinose A]
通讯作者:
Ichinose A
血球の分化における凝固XIII因子Aサブユニットの関与について
凝血因子 XIII A 亚基参与血细胞分化
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nakane T, Nakamae H, Koh H, Nakamae M, Hayashi Y, Nishimoto M, Yoshimura T, Inoue E, Inoue A, Aimoto R, Aimoto M, Terada Y, Koh KR, Yamane T, Hino M, 惣宇利正善]
通讯作者:
惣宇利正善
Is acquired hemophilia XIII(autoimmune FXIII deficiency)an overlooked or forgotten disease in europe?
获得性血友病 XIII(自身免疫性 FXIII 缺乏症)在欧洲是一种被忽视或遗忘的疾病吗?
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[原田佳代, 池田和彦, 松本勇人, 高橋裕志, 七島晶子, 大河原浩, 野地秀義, 田崎和洋, 小川一英, 阿部正文, 竹石恭知, Ichinose A]
通讯作者:
Ichinose A
Spontaneous regression of the inhibitor against the coagulation factor XIII A subunit in acquired factor XIII deficiency
获得性因子 XIII 缺乏症中凝血因子 XIII A 亚基抑制剂的自发消退
DOI:
10.1160/th10-06-0355
发表时间:
2010
期刊:
Thrombosis and Haemostasis
影响因子:
6.7
作者:
[F. Ishida, K. Okubo, Toshiro Ito, N. Okumura, M. Souri, A. Ichinose]
通讯作者:
A. Ichinose
共 80 条
Molecular pathology of autoimmune hemorrhaphilia XIII/13; analysis of anti-factor XIII autoantibodies and elucidation of the mechanism of their generation
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批准号:16K09820
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2016
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负责人:ICHINOSE Akitada
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依托单位:
The Pathogenesis of Autoimmune Hemorrhaphilia XIII/13: Analysis of Anti-FXIII/13 Autoantibodies and Elucidation of Their Generation Mechanisms
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批准号:25461444
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2013
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负责人:ICHINOSE Akitada
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依托单位:
Analyses on Mechanisms for Biosynthesis and Release of Human Coagulation Factor XIII at Molecular, Cellular, and Individual Levels.
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批准号:15390297
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:2003
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负责人:ICHINOSE Akitada
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依托单位:
Analyses on Mechanisms for Biosynthesis and Release of Human Coagulation Factor XIII at Molecular, Cellular, and Individual Levels
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批准号:11470205
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:1999
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负责人:ICHINOSE Akitada
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依托单位:
Molecular and Cellular Biological Studies on Mechanisms for Biosynthesis and Release of Human Coagulation Factor XIII.
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批准号:08457271
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.93万
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财政年份:1996
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负责人:ICHINOSE Akitada
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依托单位:
Control mechanisms for expression of apolipoprotein (a) gene, a risk factor of thrombosis.
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批准号:05454327
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1993
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负责人:ICHINOSE Akitada
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依托单位:
海外基金