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Novel pathologic factors in vasculitis - comprehensive analysis by peptidomics and their clinical significance

Novel pathologic factors in vasculitis - comprehensive analysis by peptidomics and their clinical significance
血管炎新病理因素——肽组学综合分析及其临床意义
批准号:
22591087
负责人:
OZAKI Shoichi
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Peptidomic analysis revealed 7 peptides that significantly increased or decreased in sera of patients with microscopic polyangiitis (MPA) before treatment. Among them, a peptide of 1523 kDa was identified as a C-terminal 13-mer peptide of apolipoprotein A-I, hence named AC13. AC13 was found to increase only in sera of patients with active MPA and decrease after treatment. AC13 stimulated endothelial cell lines to secrete significant levels of IL-6 and IL-8. Thus, AC13 seemed to play a pathological role in MPA and serve as a novel biomarker.
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会议论文
Proteomic analyses of aortic wall in patients with abdominal aorticaneurysm.
腹主动脉瘤患者主动脉壁的蛋白质组学分析。
DOI: --
发表时间: 2011
期刊: J Cardiovasc Surg
影响因子: 1.4
作者: [Ando T, Kurokawa MS., Kato T.]
通讯作者: Kato T.
プロテオミクスによる血管炎関連因子の探索
使用蛋白质组学搜索血管炎相关因素
DOI: --
发表时间: 2010
期刊: 炎症と免疫
影响因子: --
作者: [黒川真奈絵, 高桑由希子, 加藤智啓]
通讯作者: 加藤智啓
ANCA 関連血管炎-その病態・診・治療
ANCA 相关性血管炎 - 其病理生理学、诊断和治疗
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [尾崎承一]
通讯作者: 尾崎承一
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [尾崎承一, 他]
通讯作者:
110
    Analysis of the physiological and pathological significance of HMGB protein
    • 批准号:
      19591186
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
    • 负责人:
      OZAKI Shoichi
    • 依托单位:
    Analysis of regulatory mechanisms for HMGB1 secretion and signal transduction and their clinical significance
    • 批准号:
      16390517
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.09万
    • 财政年份:
      2004
    • 负责人:
      OZAKI Shoichi
    • 依托单位:
    HMG1 protein and its receptor : their distribution and clinical significance
    • 批准号:
      13470108
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.0万
    • 财政年份:
      2001
    • 负责人:
      OZAKI Shoichi
    • 依托单位:
    Suppressive autoantibodies in rheumatoid arthritis : construction of gene-modified animals and analysis of their arthrapathy
    • 批准号:
      13557041
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.18万
    • 财政年份:
      2001
    • 负责人:
      OZAKI Shoichi
    • 依托单位:
    海外基金