Study on the function of a novel inflammatorymarker protein(LRG) in the pathogenes I s of autoimmune d I sorders

LRG是一种新的自身免疫性疾病的生物标志物，本研究对其功能进行了研究。通过蛋白质组学方法和双杂交筛选，已经鉴定出几种LRG相互作用蛋白，包括可能的受体。LRG基因敲除小鼠的产生和分析表明，LRG对小鼠的生存不利，但参与了几种免疫疾病的进展。结果表明，LRG是一个有前途的免疫疾病的目标。LRG作为潜在治疗靶点的进一步研究将与制药公司合作进行。

The uncharacterized function of LRG, a novel biomarker for autoimmune disorders, was investigated in this study. By proteomics approach and two-hybrid screening, several candidates of LRG-interacting proteins including possible receptors have been identified. Generation and analysis of LRG knockout mice have revealed that LRG is dispensable for the survival of mice, but is involved in the progression of several immune diseases. The results suggest that LRG is a promising target of immune disorders. Further studies on LRG as a potential therapeutic target will be on the way in collaboration with a pharmaceutical company.