Mechanism and prevention strategy for mesial temporallobe epilepsy following febrile status convulsion

点击翻译按钮获取中文摘要

Febrile seizures (FS) are recognized as an antecedent to the development of temporal lobe epilepsy with hippocampal sclerosis (TLE-HS). In this study, we used a rat model of FS to study the effects of inflammatory cytokines on seizure susceptibility and neuronal death in adulthood. Prolonged hyperthermia-induced seizures (pHS) were induced in male Lewis rats on P10 and 12, and IL-1β were administered twice intranasally at the seizures. Adulthood seizure susceptibility (P70) was significantly enhanced in rats receiving IL-1β together with repeated pHS, whereas no significant effects were seen in rats receiving IL-1β after a single pHS episode (P10). Significant hippocampal neuronal cell loss was observed in the CA3 region of rats receiving IL-1β together with repeated pHS. Our results are consistent with the hypothesis that excessive production of IL-1β after repeated prolonged FS could enhance adulthood seizure susceptibility and neuronal cell death, and might contribute tothe development of TLE-HS.