Development of molecular targeted therapy of bone marrow fibrosis with BACH1 transgenic mice

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We performed this study using BACH1 transgenic mice (model mice for myelofibrosis) to understand the mechanism of myelofibrosis and develop the molecular target therapy, and found the following resultsWe identified the thromboxane A synthase gene as a BACH1 target in megakaryocytes.We investigated the anti-myelofibrosis effects of hepatocyte growth factor, which has a function of suppressing fibrosis of various tissues, on BACH1 transgenic mice. However, no significant effects were observed.