Attempt the extraction of high-risk group in extramammary Paget's disease

尝试提取乳房外佩吉特病高危人群

• 批准号: 22591214
• 负责人: AOYAGI Satoru
• 金额: $ 2.91万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591214/
• 关键词: 乳房外パジェット病; ハイリスク群の抽出; 皮膚悪性腫瘍; 予後推定; 免疫染色; 皮膚腫瘍学

The present study aims to identify a reliable marker for predicting the risk of invasion and metastasis in EMPD.To confirm MUC protein expressions, we analyzed 44 specimens from 38 primary EMPD cases by immunohistochemical staining. Labeling rates of tumor cells were scored by staining intensity on a four-tiered scale (- to 3+) to investigate the correlation between the expression score of these molecular markers and the type of EMPD lesion. Invasive lesions and metastatic lymph nodes tended to express MUC5AC significantly higher than in situ lesions (P<0.01). In conclusion, the degree of MUC5AC expression may correlate with the invasiveness and progression of EMPD, and may be a useful marker for identifying high-risk EMPD cases.

本研究旨在寻找一个可靠的标记物来预测 EMPD 侵袭和转移的风险。为了确认 MUC 蛋白的表达，我们通过免疫组织化学染色分析了 38 例原发性 EMPD 病例的 44 份标本。通过四级等级（-到3+）的染色强度对肿瘤细胞的标记率进行评分，以研究这些分子标记物的表达评分与EMPD病变类型之间的相关性。侵袭性病灶和转移性淋巴结的MUC5AC表达量明显高于原位病灶（P<0.01）。总之，MUC5AC表达程度可能与EMPD的侵袭性和进展相关，并且可能是识别高危EMPD病例的有用标志物。

项目成果

Controlling the histological margin for non-melanoma skin cancer conveniently using a double-bladed scalpel.

使用双刃手术刀方便地控制非黑色素瘤皮肤癌的组织学边缘。

• 发表时间: 2010
• 期刊: Journal of Surgical Oncology
• 影响因子: 2.5
• 作者: Aoyagi S;Hata H;et al.
• 通讯作者: et al.

Diagnostic pitfalls of using dermoscopic features to differentiate between malignant melanoma and pigmented seborrhoeic keratosis.

使用皮肤镜特征区分恶性黑色素瘤和色素沉着脂溢性角化病的诊断陷阱。

• 发表时间: 2010
• 期刊: Acta Dermmato Venereol
• 作者: Aoyagi S;Hata H;et al.
• 通讯作者: et al.