evelopment ofprognostic models for predicting the outcome of cutaneous T-cell lymphomas based on biological prognostic factors

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To develop a prognostic model for predicting the outcome of primary 'cutaneous-type' ATL, prognostic factors in the smoldering-type ATL patients with cutaneous lesions were analyzed. Independent prognostic factors for poor overall survival in multivariate analyses were higher age, high serum LDH, and higher soluble IL-2 receptor levels, while erythroderma and CXCR3 expression on tumor cells were associated with good survival. High serum LDH and higher soluble IL-2 receptor levels were also associated with higher risk for acute crisis or death from ATL. Patients with erythroderma or CXCR3-/T-bet-expressing tumor cells had lower risk for disease progression.