Glutamate concentration in the brain of individuals with autism: A proton magnetic resonance spectroscopy study.

自闭症患者大脑中的谷氨酸浓度：质子磁共振波谱研究。

• 批准号: 22591281
• 负责人: YOSHIHARA Yujiro
• 金额: $ 3.08万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591281/
• 关键词: 児童; 思春期精神医学; 分子イメージング; 自閉症; 磁気共鳴スペクトル法; グルタミン酸; 脳構造; 拡散テンソル画像法; MRS; 拡散強調画像; 核磁気共鳴スペクトロスコピー; 拡散強調テンソル画像

The aim of the present study was to examine possible alterations in the glutamatergic neurotransmitter system in the autistic brain by means of magnetic resonance spectroscopy (MRS). We measured concentrations of glutamate and glutamine as well as major metabolites such as N-acetylaspartate, choline, and creatine by MRS using 3-T scanner in 35 non-medicated subjects with autism and 35 age- and sex-matched controls. Regions of interest were placed over the cerebellar vermis, medial frontal cortices, basal ganglia, and amygdala -hippocampal complex. As a result, there was no significant difference in concentrations of any of metabolites throughout regions of interest measured between subjects with autism and controls. The current MRSstudy failed to support alterations in the glutamatergic neurotransmission in autism reported by some previous studies.

本研究的目的是通过磁共振波谱（MRS）检查自闭症患者大脑中多巴胺能神经递质系统的可能改变。我们测量浓度的谷氨酸和谷氨酰胺以及主要代谢产物，如N-乙酰天冬氨酸，胆碱，肌酸MRS使用3-T扫描仪在35个非药物治疗的自闭症患者和35个年龄和性别匹配的对照。感兴趣的区域被放置在小脑蚓部、内侧额叶皮质、基底神经节和杏仁核-海马复合体上。结果，在患有自闭症的受试者和对照者之间测量的整个感兴趣区域的任何代谢物的浓度没有显著差异。目前的MRS研究未能支持先前一些研究报告的自闭症患者中多巴胺能神经传递的改变。

项目成果

Discrimination of Autistic Adults from Controls using data on Whole-Brain MRI in a Japanese Sample

使用日本样本中的全脑 MRI 数据区分自闭症成人和对照组

• 发表时间: 2011
• 作者: 黒滝直弘;中根秀之;Yuiiro Yoshihara
• 通讯作者: Yuiiro Yoshihara

Metabolite alterations in the hippocampus of high-functioning adult subjects withautism

高功能成人自闭症受试者海马代谢的改变

• 发表时间: 2010
• 期刊: Int J Neuropsychopharmacol.
• 作者: Suzuki K;Nishimura K;Sugihara G;Nakamura K;Tsuchiya KJ;Matsumoto K,Takebayashi K;Isoda H;Sakahara H;Sugiyama T;Tsujii M;Takei N;Mori N
• 通讯作者: Mori N

Microglial Activation in Young Adults With Autism Spectrum Disorder

• DOI: 10.1001/jamapsychiatry.2013.272
• 发表时间: 2013-01-01
• 期刊: JAMA PSYCHIATRY
• 影响因子: 25.8
• 作者: Suzuki, Katsuaki;Sugihara, Genichi;Mori, Norio
• 通讯作者: Mori, Norio

Effects of Brain Amyloid Deposition and Reduced Glucose Metabolism on the Default Mode of Brain Function in Normal Aging

• DOI: 10.1523/jneurosci.2535-11.2011
• 发表时间: 2011-08-03
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Kikuchi, Mitsuru;Hirosawa, Tetsu;Ouchi, Yasuomi
• 通讯作者: Ouchi, Yasuomi

Reduced acethlcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders.

患有自闭症谱系障碍的成人梭状回乙酰胆碱酯酶活性降低。

• 发表时间: 2011
• 期刊: Arch Gen Psychiatry
• 作者: Suzuki K;Sugihara G;Ouchi Y;Nakamura K;Tsujii M;Futatsubashi M;Iwata Y;Tsuchiya KJ;Matsumoto K;Takebayashi K;Wakuda T;Yoshihara Y;Suda S;Kikuchi M;Takei N;Sugiyama T;Irie T;Mori N
• 通讯作者: Mori N