Developing a low-radiation-dose high-image-quality intelligent contrast-enhanced CT system in the era of multidetector-row CT

开发多排CT时代低辐射剂量高图像质量智能增强CT系统

• 批准号: 22591324
• 负责人: KANEMATSU Masayuki
• 金额: $ 2.08万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591324/
• 关键词: CT; インテリジェント CT; ボーラストラッキング; 低被ばく; インテリジェントCT; 多列CT; Bolus tracking; 門脈; ヨード負荷; 320列; 画像ノイズ; ヘリカル撮像

The radiation exposure per a citizen in our country leads to approximately 3.7 times of the world average. Reduction of radiation exposure in CT is urgent issue, and the usefulness of low tube voltage CT has been reported. However, the reduction of radiation dose often leads to image quality deterioration by increased image noise and the contrast decrease, and the noise reduction filter has been developed for the compensation. On the other hand, side effects such as anaphylaxis or renal dysfunction related to iodine administration, but there is not evident relation between the iodine amount of 500 mg/kg - around 750 mg/kg and such adverse events. We have conducted upper abdominal CT examinations with the iodine load of 600 mg/kg, but it is believed that the dose of 521 mg/kg is sufficient for the contrast enhancement. Based on such backgrounds,we attempted to develop bolus-tracking techniques for multiple- contrast phase using two CT s in ourhospital. I also developed a program to enable the imaging at the contrast enhancement peak of organs while setting ROIs to the aorta, pancreas, and liver parenchyma. Based on the research data,we optimized the CT examinations adjusting with body habitus of patients, decreasing radiation dose, optimizing the most effective contrast phase. We also attempted to connect the system to theintelligent contrast injector. We present these results at Radiological Society of North America in2012.

我国人均辐射暴露量约为世界平均水平的3.7倍。减少CT中的辐射暴露是一个迫切的问题，低管电压CT的有用性已经被报道。然而，辐射剂量的降低往往会导致图像噪声的增加和图像对比度的降低，从而导致图像质量的下降，为了进行补偿，人们开发了降噪滤波器。另一方面，过敏反应或肾功能障碍等副作用与碘的使用有关，但500 mg/kg - 750 mg/kg左右的碘量与这些不良事件之间没有明显的关系。我们进行了上腹部CT检查，碘负荷为600 mg/kg，但认为521 mg/kg的剂量足以增强对比。基于这样的背景，我们尝试在我院使用两台CT开发多对比期的药物跟踪技术。我还开发了一个程序，使成像在器官的对比增强峰，同时设置roi到主动脉，胰腺和肝实质。根据研究数据，优化CT检查，调整患者体质，降低放射剂量，优化最有效的造影期。我们还尝试将系统连接到智能造影剂注入器。我们在2012年的北美放射学会上发表了这些结果。

项目成果

Automatic Organ Localization in X-ray Torso CT Images Using Machine-learning Approach

使用机器学习方法在 X 射线躯干 CT 图像中自动进行器官定位

• 发表时间: 2011
• 作者: Xiangrong Zhou;Takeshi Hara ;Huayue Chen;Ryujiro Yokoyama;Masayuki Kanematsu;Hiroshi Fujita
• 通讯作者: Hiroshi Fujita

CT of the pancreas: comparison of anatomic structure depiction, image quality, and radiation exposure between 320-detector volumetric images and 64-detector helical images.

• DOI: 10.1148/radiol.11101459
• 发表时间: 2011-07
• 期刊: Radiology
• 影响因子: 19.7
• 作者: S. Goshima;M. Kanematsu;H. Nishibori;Kota Sakurai;D. Miyazawa;Haruo Watanabe;H. Kondo;Y. Shiratori;M. Onozuka;N. Moriyama;K. Bae

腹部造影CT－最適検査の標準化に向けての今後の視点－

腹部增强 CT - 最佳检查标准化的未来前景 -

• 发表时间: 2012
• 作者: 松尾信郎、中嶋憲一;他;兼松雅之
• 通讯作者: 兼松雅之

Liver CT : Optimal Iodine Load and Radiation Dose Reduction

肝脏 CT：最佳碘负荷和减少辐射剂量

• 发表时间: 2010
• 作者: Hiroshi Kawada;Satoshi Goshima;Masayuki Kanematsu;Hiroshi Kondo;Haruo Watanabe;Kyongtae Tyler Bae.;井上美香;中本裕士;中本裕士;中本裕士;中本裕士;中本裕士;Kanematsu M
• 通讯作者: Kanematsu M

Will CT take second billing to MR imaging for the diagnosis of hypervascular hepatocellular carcinomas hereafter?

今后CT在诊断富血管性肝细胞癌方面是否会仅次于MR成像？

• DOI: 10.1148/radiol.11110345
• 发表时间: 2011
• 期刊: Radiology
• 影响因子: 19.7
• 作者: M. Kanematsu