Research of incorporation of hepatic perfusion analysis using bigh-spatialresolution MRimaging

使用大空间分辨率磁共振成像进行肝脏灌注分析的研究

• 批准号: 18591337
• 负责人: KANEMATSU Masayuki
• 金额: $ 1.1万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591337/
• 关键词: Liver; Cirrhosis; MR imaging; Perfusion; hepatic blood flow; 肝血流; 肝機能; 肝予備能; ナビゲータ補正; 三次元撮像; ガドリニウム; 3Dシーケンス

We performed perfusion analysis of the liver after giving 5-mL gadolinium-chelate contrast material. After obtaining conventional dynamic. MR imaging of the liver, single-level cine. MR imaging was performed with 5-mL gadolinium contrast for perfusion analysis with dual-input-one-compartment model. We obtained hepatic blood flow ; hepatic, blood volume, mean transit time, and arterial-portal fraction. We evaluated if preceding dynamic MR imaging did not hamper the efficacy of subsequent perfusion imaging. We used algorithm of dual-input one-compartment model (Materne R, et. al. Magn Reson Med 2002 ; 47:135) for perfusion analysis. Several parameters derived from the analysis were correlated with clinical stages of chronic liver damage or cirrhosis, pathological stage of hepatic fibrosis, Child-Pugh score, and ICG15 test value. We found that our methodology for MR perfusion nalysis reflected the degree of hepatic fibrosis to a certain extent. We still need to solve some problems in the technical aspects to increase the accuracy of this technique.

我们在给予5 mL钆螯合物造影剂后进行肝脏灌注分析。获得常规动力后。肝脏MR成像，单水平电影。MR成像采用5 mL钆对比剂，采用双输入一室模型进行灌注分析。我们获得了肝血流量、肝血容量、平均通过时间和动脉-门静脉分数。我们评估了先前的动态MR成像是否不会妨碍后续灌注成像的有效性。我们使用双输入一室模型（Materne R，et.等人Magn Reson Med 2002 ; 47：135）用于灌注分析。分析得出的几个参数与慢性肝损伤或肝硬化的临床分期、肝纤维化的病理分期、Child-Pugh评分和ICG 15检测值相关。我们发现我们的MR灌注分析方法在一定程度上反映了肝纤维化的程度。我们还需要解决一些技术方面的问题，以提高这项技术的准确性。

项目成果

Classification of cirrhotic liver in gadolinium-enhanced MR images

钆增强 MR 图像中肝硬化肝脏的分类

• 发表时间: 2007
• 期刊: Computer-Aided Diagnosi 6514
• 作者: Lee G;Uchiyama Y;Zhang X;Kanematsu M;Zhou X;Hara T;Kato H;Kondo H;Fujita H;Hoshi H.
• 通讯作者: Hoshi H.

Gadolinium-enhanced Three-dimensional MR Imaging of the Liver: Optimizing Imaging Delay for Early, Late Hepatic Arterial, and Portal Venous Phases in the Detection of Hypervascular Hepatocellular Carcinomas.

肝脏钆增强三维 MR 成像：优化富血管性肝细胞癌检测中早期、晚期肝动脉和门静脉阶段的成像延迟。

• 发表时间: 2007
• 作者: Watanabe H;Goshima S;Kondo H;Tsuge Y;Yokoyama R;Kanematsu M.
• 通讯作者: Kanematsu M.

Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver: correlation with MR imaging and angiographically assisted CT

• DOI: 10.1007/s00261-005-0091-4
• 发表时间: 2006-01-01
• 期刊: ABDOMINAL IMAGING
• 作者: Kanematsu, M;Osada, S;Moriyama, N
• 通讯作者: Moriyama, N

Double hepatic arterial phase MRI of the liver with switching of reversed centric and centric K-space reordering

具有反向中心和中心 K 空间重排序切换的肝脏双肝动脉期 MRI

• 发表时间: 2006
• 期刊: Am J Romilgenol 187(2)
• 作者: Kanematsu;M.;Goshima;S.;Kondo;II.;Yokoyama;R.;Kajita;K.;IIoshi;II.;Onozuka;M.;Nozaki;A.;Hirano;M.;Shiratori;Y.;Moriyama;N
• 通讯作者: N

Gadolinium-enhanced multiphasic 3D MRI of the liver with prospective adaptive navigator correction: Phantom study and preliminary clinical evaluation

• DOI: 10.2214/ajr.06.0748
• 发表时间: 2007-04-01
• 期刊: AMERICAN JOURNAL OF ROENTGENOLOGY
• 影响因子: 5
• 作者: Kanematsu, Masayuki;Goshima, Satoshi;Moriyama, Noriyuki
• 通讯作者: Moriyama, Noriyuki