Research of incorporation of hepatic perfusion analysis using bigh-spatialresolution MRimaging

我们在给予5 mL钆螯合物造影剂后进行肝脏灌注分析。获得常规动力后。肝脏MR成像，单水平电影。MR成像采用5 mL钆对比剂，采用双输入一室模型进行灌注分析。我们获得了肝血流量、肝血容量、平均通过时间和动脉-门静脉分数。我们评估了先前的动态MR成像是否不会妨碍后续灌注成像的有效性。我们使用双输入一室模型（Materne R，et.等人Magn Reson Med 2002 ; 47：135）用于灌注分析。分析得出的几个参数与慢性肝损伤或肝硬化的临床分期、肝纤维化的病理分期、Child-Pugh评分和ICG 15检测值相关。我们发现我们的MR灌注分析方法在一定程度上反映了肝纤维化的程度。我们还需要解决一些技术方面的问题，以提高这项技术的准确性。

We performed perfusion analysis of the liver after giving 5-mL gadolinium-chelate contrast material. After obtaining conventional dynamic. MR imaging of the liver, single-level cine. MR imaging was performed with 5-mL gadolinium contrast for perfusion analysis with dual-input-one-compartment model. We obtained hepatic blood flow ; hepatic, blood volume, mean transit time, and arterial-portal fraction. We evaluated if preceding dynamic MR imaging did not hamper the efficacy of subsequent perfusion imaging. We used algorithm of dual-input one-compartment model (Materne R, et. al. Magn Reson Med 2002 ; 47:135) for perfusion analysis. Several parameters derived from the analysis were correlated with clinical stages of chronic liver damage or cirrhosis, pathological stage of hepatic fibrosis, Child-Pugh score, and ICG15 test value. We found that our methodology for MR perfusion nalysis reflected the degree of hepatic fibrosis to a certain extent. We still need to solve some problems in the technical aspects to increase the accuracy of this technique.