Efficacy of donepezil HCl to higher brain dysfunction after radiation therapy

我们对放射治疗后的高脑功能障碍进行了临床试验。在此期间，本研究入组了4例病例。1例胶质母细胞瘤患者、1例低级别胶质瘤患者、1例CNS淋巴瘤患者和1例转移性脑肿瘤患者。男3例，女1例。年龄分别为30岁、67岁、72岁。2例患者照射野为全脑照射，2例患者为局部照射。放射剂量范围为30-60戈伊。在所有病例中观察到盐酸多奈哌齐的疗效。没有病例发生2级以上的发病率。总之，盐酸多奈哌齐似乎是治疗放射治疗后脑功能障碍的有效和安全的治疗选择

We peformed clinical trials against higher brain dysfunction after radiation therapy. Among this period, 4 cases were enrolled in this study. There were a patient with glioblastoma, a patient with low grade glioma, a patients with CNS lymphoma, and a patient with metastatic brain tumor. There were 3 male and 1 female patients. They were 30, 67, 72 years old, respectively. Radiation fields were set as whole brain irradiation in 2 patients, and localized fields in other 2 patients. Radiation doses were ranging from 30-60 Gy. Efficacy of donepezil HCl were observed in all cases. There were no case who experienced more than Grade 2 morbidity. In conclusion, donepezil HCl seemed to be effective and safe treatment option against higher brain dysfunction after radiation therapy