The responsiveness of ALDH1-positive cells to chemotherapy in metastatic lesions and its prognostic significance in patients with breast cancer

本研究揭示了乳腺癌原发和转移灶中aldh1阳性细胞对化疗的反应性及其与预后的相关性。aldh1阳性细胞在淋巴结阳性乳腺癌患者中可能作为一种新的替代标志物。在未来，aldh1阳性细胞可能用于诊断和治疗，这些细胞群可能成为开发新化疗药物的靶点。我们希望我们的结果将为针对肿瘤细胞亚群的治疗提供基础数据，而不是针对无法治愈的转移性乳腺癌患者的整个身体。

In this study, the responsiveness of ALDH1-positive cells to chemotherapy in primary and metastatic lesions and its associated prognostic significance were revealed in patients with breast cancer. ALDH1-positive cells may represent a surrogate marker as a new concept in patients with lymph node-positive breast cancer. In the future, ALDH1-positive cells may be used for diagnosis and treatment, and these cell populations could be targeted in the development of new chemotherapies. We hope that our results will provide basic data for therapies targeting cell subpopulations in tumors,rather than the whole body, in patients with noncurable, metastatic breast cancer.