Prevention ofhepatocellularcarcinoma development through inhibition of AP-1 by EGCG

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In the liver cancer tissue of EGF transgenic mice, the increased expression of c-jun and activity of AP-1 were shown to increase. In addition, the intraabdominal administration of EGCG suppressed hepatocarcinogenesis. These in vivoresults were similar to in vitroones that we revealed previously. Furthermore, when we examined the signaling pathways of human liver cancer tissue, the recurrence-free survival in patients with higher expression of c-Jun was significantly lower than that in patients with lower expression of c-jun.