Distribution of Th17 cells related to regulatory T cells withintumor-microenvironment in cancer-bearing hosts.

荷癌宿主肿瘤微环境中与调节性 T 细胞相关的 Th17 细胞分布。

• 批准号: 22591452
• 负责人: MIZUKAMI Yoshiki
• 金额: $ 2.91万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591452/
• 关键词: 胃十二指腸外科学; 癌免疫療法; 胃癌; Th17; Treg; Foxp3; 癌ワクチン療法; 癌微小環境; IL-17; 制御性T細胞; アポトーシス; 酸化ストレス; ノックアウトマウス; Th17細胞; Th1; Th2

In TILs(tumor-infiltrating lymphocytes) from patient with advanceddisease of gastric cancer, the frequency of Th17 cells was also significantly higher,but lower compared to early disease, than that in the normal gastric mucosa. In conclusion,the accumulation of Th17 cells as well as Treg in the tumor microenvironment of gastriccancer occurred in early disease and then the infiltration of Th17 cells graduallydecreased according to disease progression, in contrast to increased Treg.

进展期胃癌患者的肿瘤浸润淋巴细胞（TIL）中Th17细胞的频率也明显高于正常胃粘膜，但低于早期胃癌患者。综上所述，胃癌患者的肿瘤微环境中Th17细胞和Treg在疾病早期即有积聚，随着疾病的进展，Th17细胞的浸润逐渐减少，而Treg则逐渐增加。

项目成果

Immunonutritional diet modulates natural killer cell activation and Th17 cell distribution in patients with gastric and esophageal cancer.

• DOI: 10.1016/j.nut.2010.07.007
• 发表时间: 2011-02
• 期刊: Nutrition
• 影响因子: 4.4
• 作者: T. Maruyama;K. Mimura;S. Izawa;Shugo Shiba;Mitsuaki Watanabe;Y. Kawaguchi;H. Fujii;K. Kono

進行再発食道癌に対するDocetaxel/CDDP/5-FU(DCF)療法の検討

多西紫杉醇/CDDP/5-FU（DCF）治疗晚期和复发性食管癌的研究

• 发表时间: 2011
• 作者: 武田茂;河口賀彦
• 通讯作者: 河口賀彦

Inverse correlation of HER2 with MHC class I expression on oesophageal squamous cell carcinoma.

• DOI: 10.1038/sj.bjc.6605772
• 发表时间: 2010-08-10
• 期刊: British journal of cancer
• 影响因子: 8.8

Expression of MHC Class I on breast cancer cells correlates inversely with HER2 expression.

• DOI: 10.4161/onci.21056
• 发表时间: 2012-10-01
• 期刊: Oncoimmunology
• 影响因子: 7.2
• 作者: Inoue M;Mimura K;Izawa S;Shiraishi K;Inoue A;Shiba S;Watanabe M;Maruyama T;Kawaguchi Y;Inoue S;Kawasaki T;Choudhury A;Katoh R;Fujii H;Kiessling R;Kono K
• 通讯作者: Kono K

HER-1(EGFR), HER-2 を分子標的とした食道扁平上皮癌に対する新規治療-外科治療に対する有効な補助療法-(シンポジウム)

靶向HER-1(EGFR)和HER-2的食管鳞状细胞癌新疗法 - 手术治疗的有效辅助疗法 - (研讨会)

• 发表时间: 2011
• 作者: Takehiko Yokobori;Ryo Takahashi;Yuji Kumakura;Hiroaki Honjo;Keigo Hara;Makoto Sakai;Makoto Sohda;Tatsuya Miyazaki;Takayuki Asao;Hiroyuki Kuwano;Yoshihiro Takemoto;河野浩二
• 通讯作者: 河野浩二