The new strategy of NK cell therapy with death receptors for the patients with chollangiocellular carcinoma or mixed liver cancer

死亡受体NK细胞治疗胆管细胞癌或混合性肝癌的新策略

• 批准号: 22591505
• 负责人: AMANO Hironobu
• 金额: $ 3万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591505/
• 关键词: 胆管細胞癌; Death receptor; NK細胞療法; ムチンタンパク; ムチンコアタンパク

We investigated the new strategy of natural killer (NK) cell therapy for patients with cholangiocellular carcinoma (CCC) and mixed liver cancer that were highly malignant type of liver cancer. According to our clinical specimens of CCC, more than 90% of patients elevated DR-4 expression. On the other hand, we could detect that MUC5 was one of the independent prognostic factors in survival of CCC patients. We have also confirmed human NK cells killed HuCCT1 which was cell line of human CCC, in dose dependent manner. The facts would indicated the possibility of NK cell therapy with death receptor and Ab-dependent immune response for CCC patients.

目的探讨自然杀伤（NK）细胞治疗高度恶性的胆管细胞癌（CCC）和混合型肝癌的新策略。根据我们的CCC临床标本，超过90%的患者DR-4表达升高。另一方面，我们可以检测到MUC 5是CCC患者生存的独立预后因素之一。我们还证实了人NK细胞以剂量依赖性方式杀伤人CCC细胞系HuCCT 1。这一事实提示了利用死亡受体和Ab依赖性免疫应答的NK细胞治疗CCC患者的可能性。

项目成果

Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver

• DOI: 10.1016/j.jhep.2011.04.029
• 发表时间: 2012-01-01
• 期刊: JOURNAL OF HEPATOLOGY
• 影响因子: 25.7
• 作者: Kuroda, Shintaro;Tashiro, Hirotaka;Ohdan, Hideki
• 通讯作者: Ohdan, Hideki

手術手技(生体肝移植手術手技の標準化)～次世代への匠の技の継承～

手术技术（活体肝脏移植手术技术标准化）-将技艺传承给下一代-

• 发表时间: 2010
• 作者: 天野尋暢;田代裕尊;大段秀樹;ら
• 通讯作者: ら

Therapeutic potential of propagated hepatocyte transplantation in liver failure.

• DOI: 10.1016/j.jss.2010.12.008
• 发表时间: 2011-05
• 期刊: The Journal of surgical research
• 作者: H. Amano;H. Hino;C. Tateno;K. Emoto;Y. Imaoka;C. Yamasaki;T. Itamoto;H. Tashiro;T. Asahara;H. Ohdan;K. Yoshizato

肝細胞癌術後多発再発に対する治療戦略

肝细胞癌术后多次复发的治疗策略

• 发表时间: 2012
• 作者: 天野尋暢;田代裕尊;大段秀樹ら
• 通讯作者: 大段秀樹ら

Significance of Platelet Count in the Outcomes of Hepatectomized Patients with Hepatocellular Carcinoma Exceeding the Milan Criteria

• DOI: 10.1007/s11605-011-1538-2
• 发表时间: 2011-07-01
• 期刊: JOURNAL OF GASTROINTESTINAL SURGERY
• 影响因子: 3.2
• 作者: Amano, Hironobu;Tashiro, Hirotaka;Ohdan, Hideki
• 通讯作者: Ohdan, Hideki