Is diabetes mellitus (DM) a high risk factor for coronary artery bypass grafting?

本研究的目的是确定糖尿病（DM）是否是冠状动脉旁路移植术（CABG）的高危因素。在离体人去内皮大隐静脉（SV）中，DM患者5-羟色胺（5-HT）引起的收缩（高反应性）显著大于非DM（NDM）患者。在这项研究中，我们证明，5-HT在DM患者的SV平滑肌的高反应性不仅导致肌球蛋白轻链磷酸酶（MLCP）的磷酸化增强，但也MLCP的蛋白水平的缺陷。此外，我们证明了胰岛素对5-HT诱导的SV收缩的舒张作用部分由质膜5-HT 2A受体的内化和通过PI 3-K/Akt途径产生的一氧化氮介导。总之，我们证明糖尿病是冠状动脉旁路移植术的高风险因素。

The aim of this study is to determine whether diabetes mellitus (DM) is a high risk factor for coronary artery bypass grafting (CABG). In isolated human endothelium-denuded saphenous vein (SV), the constrictions caused by 5-hydroxytryptamine (5-HT) were significantly greater (hyperreactivity) in the DM patients than in the non-DM (NDM) patients. In the study, we demonstrated that the hyperreactivity to 5-HT in the SV smooth muscle of DM patients resulted from not only the enhanced phosphorylation of myosin light chain phosphatase (MLCP) but also the defective protein levels of MLCP. Furthermore, we demonstrated that the relaxant effect of insulin on 5-HT-induced constriction of SV is mediated in part by the internalization of plasma membrane 5-HT2A receptors and the production of nitric oxide via the PI3-K/Akt pathway. In conclusion,we demonstrated that DM is a high risk factor for CABG.