Investigation of the molecular mechanism of invasion in CNS lymphomausing inoculation animal models in the brain and development of noveltreatment

中枢神经系统淋巴瘤接种动物模型脑侵袭分子机制研究及新疗法开发

• 批准号: 22591615
• 负责人: MAKINO Keishi
• 金额: $ 2.91万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591615/
• 关键词: 脳腫瘍学; 悪性リンパ腫; fatty acid synthase; IDH1; エネルギー代謝; 中枢神経; 悪性腫瘍; glucose transporter 1; 動物モデル; 浸潤; eIF4E; α2,6-sialyltransferase

In order to identify the molecules related to growth and invasion ofcentral nervous system (CNS) lymphoma, we investigated the expression of glucosetransporter 1 (Glut 1), fatty acid synthase (F AS) and 2, 6-sialyltransferase. Weperformed immunohistochemical analysis using specific antibodies for each molecule. Intwenty-three of twenty-five cases with CNS lymphomas and all nine cases with CNSinvasion of systemic lymphoma, positive expression of 2,6-sialyltransferase was found.Furthermore, positive expression of F AS was found in 70.3 % and that of Glut 1 was foundin 44.4 % of twenty-seven cases with lymphomas. These data suggested that thesemetabolic or invasion related molecules might be novel therapeutic targets for CNSlymphoma

为探讨中枢神经系统（CNS）淋巴瘤生长和侵袭的相关分子，我们研究了葡萄糖转运蛋白1（Glut 1）、脂肪酸合成酶（FAS）和2，6-唾液酸转移酶（2，6-sialyltransferase）在CNS淋巴瘤中的表达。我们使用每个分子的特异性抗体进行免疫组织化学分析。25例中枢神经系统淋巴瘤中23例2，6-sialyltransferase表达阳性，9例中枢神经系统淋巴瘤中9例2，6-sialyltransferase表达阳性，27例中枢神经系统淋巴瘤中FAS表达阳性率为70.3%，Glut 1表达阳性率为44.4%。这些结果提示，这些代谢或侵袭相关分子可能成为CNS淋巴瘤治疗的新靶点

项目成果

悪性脳腫瘍におけるfatty acid synthaseの発現とその意義

脂肪酸合酶在恶性脑肿瘤中的表达及意义

• 发表时间: 2011
• 作者: 牧野敬史;他
• 通讯作者: 他

二次性脳内悪性リンパ腫の治療成績の検討

继发性脑内恶性淋巴瘤的治疗效果检查

• 发表时间: 2010
• 作者: 牧野敬史;他;東 洋一郎;八幡 俊男;牧野敬史
• 通讯作者: 牧野敬史

Therapy-associated secondary tumors in patients with non-germinomatous malignant germ cell tumors

非生殖细胞恶性生殖细胞肿瘤患者的治疗相关继发性肿瘤

• 发表时间: 2011
• 期刊: J Neurooncol
• 作者: Nakamura H;Makino K;Ushio Y;Arima R;Kuratsu J
• 通讯作者: Kuratsu J

M2 Macrophage/Microglial Cells Induce Activation of Stat3 in Primary Central Nervous System Lymphoma

• DOI: 10.3960/jslrt.51.93
• 发表时间: 2011-11-01
• 期刊: JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY
• 影响因子: 1.5
• 作者: Komohara, Yoshihiro;Horlad, Hasita;Takeya, Motohiro
• 通讯作者: Takeya, Motohiro

Population-based epidemiological study of primary intracranial tumors in childhood

• DOI: 10.1007/s00381-010-1126-x
• 发表时间: 2010-08-01
• 期刊: CHILDS NERVOUS SYSTEM
• 影响因子: 1.4
• 作者: Makino, Keishi;Nakamura, Hideo;Kuratsu, Jun-ichi
• 通讯作者: Kuratsu, Jun-ichi