Basic research about leg dysfunction in spina bifida

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We developed surgery-induced chick SBA(1) SBA chicks exhibited leg muscle paralysis.(2) Histological analyses revealed fewer interneurons in SBA chicks than in normal chicks, but no difference was observed in the number of motor neurons.(3) a defect in the production and elimination of excess motor neurons during the early developmental stages in SBA chicks may be involved in the pathological mechanism of the motor complications of this disease.(4) The dorsal funiculus was smaller in hatched SBA chicks than in the normal controls. Degenerated sensory nerve fibers were observed in all funiculi of SBA chicks.(5) Delay in synaptogenesis and tissue maturation in SBA chicks was shown.