Functional analysis of Smoothened in osteosarcoma via signal cross talk

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We have examined the function of Hedgehog pathway in osteosarcoma cell proliferation, metastasis, and cancer stem cells. We found activation of Hedgehog pathway in human osteosarcoma. Inhibition of Smoothened (SMO) prevented osteosarcoma cell proliferation by cell cycle regulation in vitro and in vivo. In addition, pharmacological inhibition of SMO or GLI prevents human rhabdomyosarcoma cell proliferation. Furthermore, inhibition of GLI2 prevents osteosarcoma cell proliferation, invasion, and lung metastasis. We have already found that other signal related molecule regulate the osteosarcoma cell metastasis by Hedgehog signal activation.