Modification of general anesthetic actions in hippocampus of the Alzheimer-type dementia model mice

阿尔茨海默型痴呆模型小鼠海马全身麻醉作用的改变

• 批准号: 22591704
• 负责人: HIROTA Koki
• 金额: $ 2.75万
• 依托单位: University of Toyama
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591704/
• 关键词: 認知症; アルツハイマー病; 海馬; シナプス電位; GABA; 全身麻酔薬; 全身麻酔; セボフルラン; 疾患モデルマウス; 抑制性シナプス伝達; 再取り込み; 認知症モデルマウス

Clinical anesthesiologists have an increasing opportunity to anesthetize elderly patients with dementia. In order to investigate whether the senile dementia modifies the anesthetic actions in the central nervous systems, we have studied effects of general anesthetics on the hippocampal synaptic transmission in the senescence-accelerated mice (SAM-P8 and SAM-R1). The characteristic feature of SAM-P8 mouse shows Alzheimer-type deficits in learning and memory, whereas SAM-R1 mouse has no neurological impairment. Field population spikes of CA1 pyramidal neurons were elicited, following the activation of recurrent inhibition. The pre-pulses were applied as train stimuli to activate release and then deplete GABA. Volatile and intravenous anesthetics had greater actions on inhibitory synaptic transmission in SAM-P8 than in SAM-R1, due to the increase in GABA release from presynaptic terminals.

临床麻醉师有越来越多的机会麻醉老年痴呆症患者。为了探讨老年性痴呆是否改变了中枢神经系统的麻醉作用，我们研究了全身麻醉药对快速老化小鼠（SAM-P8和SAM-R1）海马突触传递的影响。SAM-P8小鼠在学习和记忆方面表现出阿尔茨海默型缺陷，而SAM-R1小鼠没有神经功能障碍。CA 1区锥体神经元的场群体峰电位被激发，随后激活复发抑制。施加前脉冲作为训练刺激以激活释放，然后耗尽GABA。与SAM-R1相比，挥发性和静脉麻醉药对SAM-P8的抑制性突触传递作用更大，这是由于突触前末梢释放的GABA增加。

项目成果

麻酔科医の目から見た医療安全のピットフォール

麻醉师视角下的医疗安全陷阱

• 发表时间: 2013
• 期刊: 医報とやま
• 作者: 加藤佳子;宮本善一;ほか;廣田弘毅
• 通讯作者: 廣田弘毅

Senile dementia enhances the actions of general anesthetics on hippocampal synaptic transmission

老年痴呆增强全身麻醉药对海马突触传递的作用

• 发表时间: 2010
• 作者: Koki Hirota;Rika Sasaki;Yasuko Iwase;Mitsuaki Yamazaki.;Rika Sasaki
• 通讯作者: Rika Sasaki

中枢シナプス伝達に及ぼす全身麻酔薬の作用とその臨床的考察(シンポジウム「臨床に役立つ麻酔メカニズムBench to Bed, Bed to Bench」)

全身麻醉药对中枢突触传递的影响及其临床考虑（研讨会“临床有用的麻醉机制从工作台到床，从床到工作台”）

• 发表时间: 2010
• 作者: Yukihide Koyama;Tomio Andoh;Yoshinori Kamiya;Satoshi Morita;Tomoyuki Miyazaki;Kazuhiro Uchimoto;Takahiro Mihara;Takahisa Goto;廣田弘毅
• 通讯作者: 廣田弘毅