Mechanisms of the inhibition effects of propofol on adiponectin secretion and its role of insulin resistance

丙泊酚抑制脂联素分泌的机制及其抗胰岛素作用

• 批准号: 22591741
• 负责人: KANMURA Yuichi
• 金额: $ 3万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591741/
• 关键词: 周術期管理学; アディポネクチン; プロポフォール; インスリン; 脂肪細胞; インスリン抵抗性; シバリング

We investigated the effects and mechanisms of propofol, an intravenous anesthetics, on adiponectin, which is the protein hormone secreted from adipose tissue. Propofol dose-dependently inhibited the secretion of adiponection from cultured adipose cells, and also lowered the concentrations of adiponectin in the rats in vivo. We investigated the mechanisms of this inhibitory effects, and found that propofol directly enhanced the phosphorylation of JNK in adipose cells and inhibited the secretion of adiponectin, not by the activation of GABA receptor, which is the main target of propofol anesthetic action.

我们研究了静脉麻醉药异丙酚对脂肪组织分泌的蛋白激素脂联素的影响及其机制。异丙酚剂量依赖性地抑制培养的脂肪细胞分泌脂联素，并降低大鼠体内脂联素的浓度。我们研究了这种抑制作用的机制，发现丙泊酚直接增强脂肪细胞JNK的磷酸化，抑制脂联素的分泌，而不是通过激活GABA受体，这是丙泊酚麻醉作用的主要靶点。

项目成果

プロポフォールは脂肪細胞内伝達シグナルJNKのリン酸化を促進しアディポネクチン分泌を抑制する

丙泊酚促进脂肪细胞胞内传递信号JNK磷酸化并抑制脂联素分泌

• 发表时间: 2010
• 作者: 森山孝宏;他
• 通讯作者: 他

Perfusion Index as a Predictive Factor of Postoperative Shivering

灌注指数作为术后颤抖的预测因素

• 发表时间: 2012
• 作者: A. Yoshikawa;M. Hasegawa-Moriyama;C. Kuroki;K. Godai;K. Enohata;A. Matsunaga;Y. Kanmura
• 通讯作者: Y. Kanmura

Effects of a Novel Benzodiazepine Derivative, JM-1232(-), on Human Gastroepiploic Artery In Vitro

• DOI: 10.1053/j.jvca.2010.03.013
• 发表时间: 2011-02-01
• 期刊: JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
• 影响因子: 2.8
• 作者: Moriyama, Takahiro;Tsuneyoshi, Isao;Kanmura, Yuichi
• 通讯作者: Kanmura, Yuichi

Difference between pleth variability index obtained from the finger and the forehead

从手指和前额获得的体积变异指数之间的差异

• 发表时间: 2012
• 作者: Akira Matsunaga;et al
• 通讯作者: et al

Is exacerbation of mitral regurgitation during OPCAB anastomosis due to leaflet tethering?

OPCAB 吻合期间二尖瓣反流加剧是否是由于瓣叶栓系所致？

• 发表时间: 2011
• 作者: Naka. Imakire;et al
• 通讯作者: et al