Mechanisms of the inhibition effects of propofol on adiponectin secretion and its role of insulin resistance

我们研究了静脉麻醉药异丙酚对脂肪组织分泌的蛋白激素脂联素的影响及其机制。异丙酚剂量依赖性地抑制培养的脂肪细胞分泌脂联素，并降低大鼠体内脂联素的浓度。我们研究了这种抑制作用的机制，发现丙泊酚直接增强脂肪细胞JNK的磷酸化，抑制脂联素的分泌，而不是通过激活GABA受体，这是丙泊酚麻醉作用的主要靶点。

We investigated the effects and mechanisms of propofol, an intravenous anesthetics, on adiponectin, which is the protein hormone secreted from adipose tissue. Propofol dose-dependently inhibited the secretion of adiponection from cultured adipose cells, and also lowered the concentrations of adiponectin in the rats in vivo. We investigated the mechanisms of this inhibitory effects, and found that propofol directly enhanced the phosphorylation of JNK in adipose cells and inhibited the secretion of adiponectin, not by the activation of GABA receptor, which is the main target of propofol anesthetic action.