A clinical study to investigate effects of various genomic single nucleotide polymorphisms (SNPs) on analgesic and adverse effects of opioid analgesics

在目前的研究中，我们再次证实了人类μ-阿片受体基因118A/G的单核苷酸多态性降低了阿片类药物的敏感性，增加了术后阿片类药物的需求。我们还发现，跨越2q33.3-2q34的连锁不平衡区块内的遗传多态与术后阿片类药物需求密切相关。SNP的C等位基因rs2952768与更多的止痛需求相关。此外，该SNP中C等位基因携带者对严重药物依赖的易感性较低。我们的发现为疼痛和药物依赖的个性化治疗提供了有价值的信息。

In the current study, we reconfirmed that a single nucleotide polymorphism (SNP), 118A/G of the human μ -opioid receptor gene decreased opioid sensitivity and increased postoperative opioid requirements. We also found that genetic polymorphisms within a linkage disequilibrium block that spans 2q33.3 -2q34 were strongly associated with postoperative opioid requirements. The C allele of the SNP, rs2952768, was associated with more analgesic requirements. In addition, carriers of the C allele in this SNP exhibited less vulnerability to severe drug dependence. Our findings provide valuable information for the personalized treatment of pain and drug dependence.