Roles of irradiated stromal cells in the survival, growth , invasion of prostate carcinoma and its mechanisms

点击翻译按钮获取中文摘要

Adipocytes and adipose tissues, adipose tissue stromal cells (ATSC) promote the invasion of prostate cancer cell line (PC3), but the irradiated stromal cell types do not significantly affect the invasion of PC3. Irradiated ATSC tends to promote the growth of prostate cancer cell line (LNcap). To evaluate effects of irradiated stromal cells on tumor cells other than prostate tumor cells, we used bladder tumor cells in this research project. Irradiated ATSC inhibits the growth of superficial bladder cancer cell line (RT4), and promotes the apoptosis. In contrast, irradiated ATSC promotes the growth of invasive bladder cancer cell line (EJ) and inhibits the apoptosis. IrradiatedATSC promotes the expression of MAP kinase pathway in these cancer cell types.These results suggest that irradiated stromal cell types may affect tumor growth and invasion in a tumor cell type-dependent way at least in prostatic adenocarcinoma and bladder urinary carcinoma. To estimate effects of irradiated stromal cell types on prostate and bladder cancers in more detail, further studies are needed.交付決定