Roles of irradiated stromal cells in the survival, growth , invasion of prostate carcinoma and its mechanisms

辐照基质细胞在前列腺癌生存、生长、侵袭中的作用及其机制

• 批准号: 22591770
• 负责人: UOZUMI Jiro
• 金额: $ 2.75万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591770/
• 关键词: 前立腺癌; 放射線被爆間質; 癌間質相互作用; 放射線被曝線維芽細胞; 脂肪細胞; 増殖; 浸潤; 脂肪組織由来間質線維芽細胞(ATSC)

Adipocytes and adipose tissues, adipose tissue stromal cells (ATSC) promote the invasion of prostate cancer cell line (PC3), but the irradiated stromal cell types do not significantly affect the invasion of PC3. Irradiated ATSC tends to promote the growth of prostate cancer cell line (LNcap). To evaluate effects of irradiated stromal cells on tumor cells other than prostate tumor cells, we used bladder tumor cells in this research project. Irradiated ATSC inhibits the growth of superficial bladder cancer cell line (RT4), and promotes the apoptosis. In contrast, irradiated ATSC promotes the growth of invasive bladder cancer cell line (EJ) and inhibits the apoptosis. IrradiatedATSC promotes the expression of MAP kinase pathway in these cancer cell types.These results suggest that irradiated stromal cell types may affect tumor growth and invasion in a tumor cell type-dependent way at least in prostatic adenocarcinoma and bladder urinary carcinoma. To estimate effects of irradiated stromal cell types on prostate and bladder cancers in more detail, further studies are needed.交付決定

Adipocytes and adipose tissues, adipose tissue stromal cells (ATSC) promote the invasion of prostate cancer cell line (PC3), but the irradiated stromal cell types do not significantly affect the invasion of PC3. Irradiated ATSC tends to promote the growth of prostate cancer cell line (LNcap). To evaluate effects of irradiated stromal cells on tumor cells other than prostate tumor cells, we used bladder tumor cells in this research project. Irradiated ATSC inhibits the growth of superficial bladder cancer cell line (RT4), and promotes the apoptosis. In contrast, irradiated ATSC promotes the growth of invasive bladder cancer cell line (EJ) and inhibits the apoptosis. IrradiatedATSC promotes the expression of MAP kinase pathway in these cancer cell types.These results suggest that irradiated stromal cell types may affect tumor growth and invasion in a tumor cell type-dependent way at least in prostatic adenocarcinoma and bladder urinary carcinoma. To estimate effects of irradiated stromal cell types on prostate and bladder cancers in more detail, further studies are needed.

项目成果

脂肪組織間質細胞が膀胱癌細胞の生存、増殖、浸潤に及ぼす影響

脂肪组织基质细胞对膀胱癌细胞存活、增殖和侵袭的影响

• 发表时间: 2012
• 作者: 南里麻己;その他
• 通讯作者: その他

脂肪組織間質細胞が膀胱癌組織の生存、増殖、浸潤におよぼす影響

脂肪组织基质细胞对膀胱癌组织存活、增殖和侵袭的影响

• 发表时间: 2012
• 作者: 南里麻己;その他;南里麻己,松延亜紀,内橋和芳,青木茂久,有働和馬,佐藤勇司,徳田雄治,野口満,戸田修二,魚住二郎
• 通讯作者: 南里麻己,松延亜紀,内橋和芳,青木茂久,有働和馬,佐藤勇司,徳田雄治,野口満,戸田修二,魚住二郎