Combined therapy for urologic cancer cells by high-intensity focused ultrasound and PEG-conjugated fullerene

高强度聚焦超声与 PEG 富勒烯联合治疗泌尿系癌细胞

• 批准号: 22591783
• 负责人: SUMITOMO Makoto
• 金额: $ 2.91万
• 依托单位: Aichi Medical University (2011-2012)National Defense Medical College (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591783/
• 关键词: ポリエチレングリコール; フラーレン; 癌細胞株; 収束超音波; 抗腫瘍効果; 担癌マウス; ポリエチレングリコール(PEG)

By chemically modifying fullerene (C60) with polyethylene glycol (PEG), we succeeded in synthesizing water-soluble PEG-conjugated fullerene. MTS assays showed that thecombination of HIFU with PEG-conjugated fullerene resulted in synergistic growth inhibitory effects in PC-3 cells in vitro. In vivo, however, we failed to confirm reproducibility on the results of selective tumor tissue accumulation of fullerene because of instability of labeled PEG-conjugated fullerene. Using chicken tissue model we found synergistic tissue degenerating effects by this combination therapy, which showed no additive or synergistic antitumor effects in PC-3 xenograft models.

利用聚乙二醇（PEG）对富勒烯（C60）进行化学修饰，成功地合成了水溶性PEG共轭富勒烯。MTS实验表明，HIFU与PEG结合的富勒烯在体外对PC-3细胞具有协同的生长抑制作用。然而，在体内，由于标记的PEG缀合的富勒烯的不稳定性，我们未能确认富勒烯的选择性肿瘤组织积累的结果的再现性。使用鸡组织模型，我们发现这种组合疗法的协同组织变性作用，在PC-3异种移植模型中没有显示出累加或协同抗肿瘤作用。

项目成果

Anterior perirectal fat tissue thickness is a strong predictor of recurrence after high-intensity focused ultrasound for prostate cancer

• DOI: 10.1111/j.1442-2042.2010.02585.x
• 发表时间: 2010-09-01
• 期刊: INTERNATIONAL JOURNAL OF UROLOGY
• 影响因子: 2.6
• 作者: Sumitomo, Makoto;Asakuma, Junichi;Asano, Tomohiko
• 通讯作者: Asano, Tomohiko

Transurethral resection of the prostate immediately after high‐intensity focused ultrasound treatment for prostate cancer

高强度聚焦超声治疗前列腺癌后立即行经尿道前列腺切除术

• DOI: 10.1111/j.1442-2042.2010.02638.x
• 发表时间: 2010
• 期刊: International journal of urology
• 影响因子: 2.6
• 作者: M. Sumitomo;J. Asakuma;A. Sato;K. Ito;K. Nagakura;T. Asano
• 通讯作者: T. Asano