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Combined therapy for urologic cancer cells by high-intensity focused ultrasound and PEG-conjugated fullerene

Combined therapy for urologic cancer cells by high-intensity focused ultrasound and PEG-conjugated fullerene
高强度聚焦超声与 PEG 富勒烯联合治疗泌尿系癌细胞
批准号:
22591783
负责人:
SUMITOMO Makoto
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
翻译
用聚乙二醇(PEG)对富勒烯(C60)进行化学修饰,成功地合成了水溶性的聚乙二醇共轭富勒烯。MTS实验显示,HIFU与peg共轭富勒烯联合使用对体外PC-3细胞具有协同生长抑制作用。然而,在体内,由于标记的peg共轭富勒烯的不稳定性,我们未能证实选择性肿瘤组织积累富勒烯结果的可重复性。在鸡组织模型中,我们发现该联合治疗对组织变性有协同作用,而对PC-3异种移植瘤模型无加性或协同抗肿瘤作用。
英文摘要
By chemically modifying fullerene (C60) with polyethylene glycol (PEG), we succeeded in synthesizing water-soluble PEG-conjugated fullerene. MTS assays showed that thecombination of HIFU with PEG-conjugated fullerene resulted in synergistic growth inhibitory effects in PC-3 cells in vitro. In vivo, however, we failed to confirm reproducibility on the results of selective tumor tissue accumulation of fullerene because of instability of labeled PEG-conjugated fullerene. Using chicken tissue model we found synergistic tissue degenerating effects by this combination therapy, which showed no additive or synergistic antitumor effects in PC-3 xenograft models.
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会议论文
DOI: 10.1111/j.1442-2042.2010.02585.x
发表时间: 2010-09-01
期刊: INTERNATIONAL JOURNAL OF UROLOGY
影响因子: 2.6
作者: [Sumitomo, Makoto, Asakuma, Junichi, Asano, Tomohiko]
通讯作者: Asano, Tomohiko
DOI: 10.1111/j.1442-2042.2010.02638.x
发表时间: 2010
期刊: International journal of urology
影响因子: 2.6
作者: [M. Sumitomo, J. Asakuma, A. Sato, K. Ito, K. Nagakura, T. Asano]
通讯作者: T. Asano
海外基金