Identification of the microRNA which is involved in theanti-proliferative action of estrogens

雌激素刺激雌激素反应器官的细胞增殖，包括子宫、乳腺和脑下垂体前叶。最近，我们在原代培养的大鼠催乳素细胞上发现，17-β雌二醇(E_2)具有雌激素受体介导的抗有丝分裂作用，并存在胰岛素样生长因子-1等生长因子。然而，目前，雌激素上催乳素依赖的IGF-1抗有丝分裂作用的细胞和分子机制尚不清楚。在本研究中，我们发现了可能参与雌激素抗增殖作用的microRNA。

Estrogens stimulate cell proliferation of estrogen-responsiveorgans including the uterus, mammary gland, and anterior pituitary gland. Recently, wehave found that 17-β estradiol (E2) had estrogen receptor-mediated anti-mitogenic actionin presence of growth factors such as insulin-like growth factor-1 (IGF-1) on ratlactotroph primary cell culture. However, at present, the cellular and molecularmechanisms underlying the IGF-1-dependent anti-mitogenic action of estrogen uponlactotroph remain unknown. In this study, we have found the microRNA which might beinvolved in the anti-proliferative action of estrogens.