Identification of molecular marker for placenta accreta

本研究通过高通量比较分析，鉴定了胎盘特异的mRNAs/microRNAs(MiRNAs)。关于胎盘特异的mRNAs，母体血浆中人胎盘催乳素(HPL)水平可能是胎盘合并全子宫切除的预测标志。关于胎盘特异的microRNAs(MiRNAs)，大部分位于19号染色体microRNAs簇区(C19MC)。随着妊娠的进展，C19MC上miRNAs的表达水平呈上升趋势，但表达谱无明显变化。母体血浆中C19MC上胎盘特异性miRNAs的循环水平可能是前置胎盘植入性胎盘风险的预测指标。此外，术中超声检查有望有助于评估前置胎盘胎盘附着的程度。

In this study, by high-throughput comparative analysis, placenta specific mRNAs/microRNAs (miRNAs) were identified. Regarding the placenta specific mRNAs, human placental lactogen (hPL) levels in maternal plasma may be a predictive marker for placenta accrete with total hysterectomy. Regarding the placenta specific microRNAs (miRNAs), most of them located on chromosome 19 microRNAs cluster region (C19MC). The expression levels of miRNAs on C19MC were increasing as the progress of pregnancy, while the expression profiling of them were not changed. The circulating levels of placenta specific miRNAs on C19MC in maternal plasma may be predictive markers for the risk of placenta accreta in cases of placenta previa. Furthermore, the intraoperative ultrasound examination is expected to be useful for evaluating the degree of placenta accrete in cases of placenta previa.