Identification of molecular marker for placenta accreta

侵入性胎盘分子标记的鉴定

• 批准号: 22591827
• 负责人: MASUZAKI Hideaki
• 金额: $ 3万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591827/
• 关键词: 癒着胎盤; 胎盤; mRNA; microRNA; 術中超音波検査; 母体血漿; 産婦人科; 超音波診断; 分子マーカー; RNA

In this study, by high-throughput comparative analysis, placenta specific mRNAs/microRNAs (miRNAs) were identified. Regarding the placenta specific mRNAs, human placental lactogen (hPL) levels in maternal plasma may be a predictive marker for placenta accrete with total hysterectomy. Regarding the placenta specific microRNAs (miRNAs), most of them located on chromosome 19 microRNAs cluster region (C19MC). The expression levels of miRNAs on C19MC were increasing as the progress of pregnancy, while the expression profiling of them were not changed. The circulating levels of placenta specific miRNAs on C19MC in maternal plasma may be predictive markers for the risk of placenta accreta in cases of placenta previa. Furthermore, the intraoperative ultrasound examination is expected to be useful for evaluating the degree of placenta accrete in cases of placenta previa.

本研究通过高通量比较分析，鉴定胎盘特异性mRNA/microRNA（miRNAs）。关于胎盘特异性mRNA，母体血浆中人胎盘催乳素（hPL）水平可能是全子宫切除术后胎盘附着的预测标志物。胎盘特异性microRNAs（miRNAs）主要位于19号染色体microRNAs簇区（C19 MC）。C19 MC上miRNAs的表达水平随着妊娠的进展而增加，但其表达谱没有改变。母体血浆中C19 MC上胎盘特异性miRNA的循环水平可能是前置胎盘患者胎盘植入风险的预测标志物。术中超声检查对前置胎盘植入程度的判断有重要价值。

项目成果

正常妊娠と胞状奇胎の双胎妊娠後に認められた胎盤部トロホブラスト腫瘍の一例

正常妊娠与葡萄胎双胎妊娠后观察到的胎盘滋养细胞肿瘤一例

• 发表时间: 2011
• 作者: 東島愛;吉田敦;城大空;阿部修平;谷川輝美;三浦生子;山崎健太郎;吉村秀一郎;増崎英明
• 通讯作者: 増崎英明

前置胎盤・前置癒着胎盤の手術

前置胎盘/植入性胎盘手术

• 发表时间: 2012
• 作者: 三浦清徳;東島愛;阿部修平;三浦生子;山崎健太郎;嶋田貴子;吉田敦;中山大介;増崎英明;増崎英明
• 通讯作者: 増崎英明

Human Papillomavirus DNA in Plasma of Patients with HPV16 DNA-positive Uterine Cervical Cancer

• DOI: 10.1093/jjco/hyp193
• 发表时间: 2010-05-01
• 期刊: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 2.4
• 作者: Shimada, Takako;Yamaguchi, Naohiro;Masuzaki, Hideaki
• 通讯作者: Masuzaki, Hideaki

A case of Kallmann syndrome carrying a missense mutation in alternatively spliced exon 8A encoding the immunoglobulin-like domain IIIb of fibroblast growth factor receptor 1

• DOI: 10.1093/humrep/deq006
• 发表时间: 2010-04-01
• 期刊: HUMAN REPRODUCTION
• 影响因子: 6.1
• 作者: Miura, Kiyonori;Miura, Shoko;Masuzaki, Hideaki
• 通讯作者: Masuzaki, Hideaki

Fetal response to induced maternal emotions

• DOI: 10.1007/s12576-010-0087-x
• 发表时间: 2010-05-01
• 期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES
• 影响因子: 2.3
• 作者: Araki, Miyuki;Nishitani, Shota;Shinohara, Kazuyuki
• 通讯作者: Shinohara, Kazuyuki