Elucidating a determinant of development as a novel therapeutic target of ovarian clear cell adenocarcinoma

膜联蛋白A4（annexin A4，ANXA 4）是卵巢透明细胞腺癌（ovarian clear cell adenocarcinoma，OCCA）中高表达的蛋白质之一，是典型的化疗耐药和预后差的疾病。使用了两种OCCA细胞系，其中ANXA4表达被shRNA抑制。在酸性ANXA 4表达细胞中识别出显著受限的增殖和增加的化学敏感性，而在碱性ANXA 4表达细胞中检测到侵袭性降低。

The annexin A4 (ANXA4), one of the highly expressed proteins in ovarian clear cell adenocarcinoma (OCCA), which is typically chemo-resistant and poor-prognosis disease, was our research target. Two OCCA cell lines in which ANXA4 expression is suppressed by shRNA were used. Significantly restricted proliferation and increased chemo-sensitivity were recognized in an acidic-ANXA4-expressing cell, whereas decreased invasiveness was detected in a basic-ANXA4-expressing cell.