Elucidation of the mechanism of iron action against anti-diabetes and search for a new therapeutic target of diabetes研究代表池田康将(IKEDA YASUMASA)

阐明铁抗糖尿病作用机制，寻找糖尿病新治疗靶点 研究总监池田康正（IKEDA YASUMASA）

• 批准号: 22790864
• 负责人: IKEDA Yasumasa
• 金额: $ 2.5万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790864/
• 关键词: 鉄; 肥満; 糖尿病; 酸化ストレス

It has been shown that the amount of visceral fat is related to body iron content, and body iron storage is a risk factor of the development of diabetes. We examined the effect of iron deprivation in fat tissue. Iron deprivation contributed to 1) decrease of fat weight and adipocyte size, 2) reduction of macrophage invasion in fat, 3) suppression of oxidative stress and inflammatory cytokine, 4) improvement of Akt-IRS pathway. These results suggest that iron chelation improve the development of adipocyte hypertrophy via suppression of oxidative stress, leading to the amelioration of glucose tolerance.

已有研究表明，内脏脂肪的数量与体内铁含量有关，体内铁储存是糖尿病发生的危险因素。我们研究了脂肪组织中缺铁的影响。缺铁可减少脂肪重量和脂肪细胞大小，减少脂肪中巨噬细胞的侵袭，抑制氧化应激和炎性细胞因子，改善Akt-IRS途径。这些结果表明，铁络合物通过抑制氧化应激改善脂肪细胞肥大的发展，导致糖耐量的改善。

项目成果

Pathophysiological Response to Hypoxia - From the Molecular Mechanisms of Malady to Drug Discovery:Inflammatory Responses of Hypoxia-Inducible Factor 1.ALPHA. (HIF-1.ALPHA.) in T Cells Observed in Development of Vascular Remodeling

对缺氧的病理生理反应 - 从疾病的分子机制到药物发现：缺氧诱导因子 1.ALPHA 的炎症反应。

• DOI: 10.1254/jphs.10r22fm
• 发表时间: 2011
• 期刊: Journal of Pharmacological Sciences
• 影响因子: 3.5
• 作者: Tomita S;et al
• 通讯作者: et al

Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function

• DOI: 10.1016/j.atherosclerosis.2010.05.011
• 发表时间: 2010-09-01
• 期刊: ATHEROSCLEROSIS
• 影响因子: 5.3
• 作者: Yoshida, Sumiko;Aihara, Ken-ichi;Matsumoto, Toshio
• 通讯作者: Matsumoto, Toshio

Estrogen action on iron metabolism

雌激素对铁代谢的作用

• 发表时间: 2011
• 作者: Ikeda Yasumasa;et al
• 通讯作者: et al

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Protective effect of photodegradation product of nifedipine against tumor necrosis factor alpha-induced oxidative stress in human glomerular endothelial cells

• DOI: 10.2152/jmi.58.118
• 发表时间: 2011-02-01
• 期刊: JOURNAL OF MEDICAL INVESTIGATION
• 影响因子: 0.7
• 作者: Fukuhara, Yayoi;Tsuchiya, Koichiro;Tamaki, Toshiaki
• 通讯作者: Tamaki, Toshiaki