Elucidation of the mechanism of iron action against anti-diabetes and search for a new therapeutic target of diabetes研究代表池田康将(IKEDA YASUMASA)

已有研究表明，内脏脂肪的数量与体内铁含量有关，体内铁储存是糖尿病发生的危险因素。我们研究了脂肪组织中缺铁的影响。缺铁可减少脂肪重量和脂肪细胞大小，减少脂肪中巨噬细胞的侵袭，抑制氧化应激和炎性细胞因子，改善Akt-IRS途径。这些结果表明，铁络合物通过抑制氧化应激改善脂肪细胞肥大的发展，导致糖耐量的改善。

It has been shown that the amount of visceral fat is related to body iron content, and body iron storage is a risk factor of the development of diabetes. We examined the effect of iron deprivation in fat tissue. Iron deprivation contributed to 1) decrease of fat weight and adipocyte size, 2) reduction of macrophage invasion in fat, 3) suppression of oxidative stress and inflammatory cytokine, 4) improvement of Akt-IRS pathway. These results suggest that iron chelation improve the development of adipocyte hypertrophy via suppression of oxidative stress, leading to the amelioration of glucose tolerance.