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Role of human CRP and TACE in the Pathogenesis of Adipose Tissue Remodeling and Insulin Resistance

Role of human CRP and TACE in the Pathogenesis of Adipose Tissue Remodeling and Insulin Resistance
人 CRP 和 TACE 在脂肪组织重塑和胰岛素抵抗发病机制中的作用
批准号:
22790871
负责人:
KANEKO Hidehiro
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
We aimed to clarify the role of human C-reactive protein(CRP) and TACE in the development of adipose tissue remodeling and metabolic disorders. Human CRP transgenic mice showed exacerbated adipose tissue remodeling, insulin resistance and hepatosteatosis under high-fat diet feeding. In contrast, TACE ablation mice prevented high-fat diet induced body weight gain, adipose tissue remodeling and metabolic disorders. These experiments might suggest the crucial role of human CRP and TACE in the pathogenesis of adipose tissue remodeling and metabolic disorders under high-fat diet feeding.
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Human C-reactive protein exacerbates metabolic disorders in association with adipose tissue remodeling
人类 C 反应蛋白加剧与脂肪组织重塑相关的代谢紊乱
DOI: --
发表时间: 2011
期刊: Cardiovasc Res
影响因子: 10.8
作者: [Kaneko H, Anzai T, Nagai T, Anzai A, Takahashi T, Mano M, Morimoto K, Maekawa Y, Itoh H, Yoshikawa T, Ogawa S, Fukuda K]
通讯作者: Fukuda K
Temporal Systemic Deletion of Tumor Necrosis Factor-α Converting Enzyme Prevents Development of High-Fat Diet-induced Insulin Resistance, Hepatosteatosis, Adipose Tissue Remodeling with Ameliorating Energy Expenditure
暂时性系统性删除肿瘤坏死因子-α 转换酶可防止高脂饮食引起的胰岛素抵抗、肝脂肪变性、脂肪组织重塑并改善能量消耗
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kaneko H, Anzai T, Horiuchi K, Morimoto K, Itoh H, Okada Yasunori, Yoshikawa T, Ogawa S, Fukuda K]
通讯作者: Fukuda K
Tumor necrosis factor-〓 converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis
肿瘤坏死因子-〓转换酶失活改善高脂饮食诱导的胰岛素抵抗并改变能量稳态
DOI: --
发表时间: 2011
期刊: Circulation Journal
影响因子: 3.3
作者: [Kaneko H, Anzai, T, Horiuchi, K, Morimoto K, Anzai A, Nagai T, Maekawa Y, Itoh H, Yoshikawa T, Okada Y, Ogawa S, Fukuda K, Hidehiro Kaneko, Hidehiro Kaneko, Hidehiro Kaneko]
通讯作者: Hidehiro Kaneko
Human C-reactive protein exacerbates obesity induced insulin resistance and hepatosteatosis associated with adipose tissue remodeling
人类 C 反应蛋白加剧肥胖引起的胰岛素抵抗和与脂肪组织重塑相关的肝脂肪变性
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kaneko H, Anza i T, Takah ashi T, Morimoto K, Maekawa Y, Itoh H, Yoshikawa T, Ogawa S, Fukuda K]
通讯作者: Fukuda K
6
    Application of Multi Layer Static Pile Forced Aeration Reactor for Effective Bio-drying
    • 批准号:
      19K12378
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.33万
    • 财政年份:
      2019
    • 负责人:
      KANEKO Hidehiro
    • 依托单位:
    Development and Application of Algal Toxicity Test based on Oxygen Evolution
    • 批准号:
      10680511
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.34万
    • 财政年份:
      1998
    • 负责人:
      KANEKO Hidehiro
    • 依托单位:
    海外基金