Role of human CRP and TACE in the Pathogenesis of Adipose Tissue Remodeling and Insulin Resistance

人 CRP 和 TACE 在脂肪组织重塑和胰岛素抵抗发病机制中的作用

• 批准号: 22790871
• 负责人: KANEKO Hidehiro
• 金额: $ 2.58万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790871/
• 关键词: 内臓脂肪リモデリング; インスリン抵抗性; 慢性炎症; C反応蛋白; TACE

We aimed to clarify the role of human C-reactive protein(CRP) and TACE in the development of adipose tissue remodeling and metabolic disorders. Human CRP transgenic mice showed exacerbated adipose tissue remodeling, insulin resistance and hepatosteatosis under high-fat diet feeding. In contrast, TACE ablation mice prevented high-fat diet induced body weight gain, adipose tissue remodeling and metabolic disorders. These experiments might suggest the crucial role of human CRP and TACE in the pathogenesis of adipose tissue remodeling and metabolic disorders under high-fat diet feeding.

我们旨在阐明人类C反应蛋白（CRP）和TACE在脂肪组织重塑和代谢紊乱中的作用。人CRP转基因小鼠在高脂饮食喂养下表现出脂肪组织重塑加重、胰岛素抵抗和脂肪肝。相比之下，TACE消融小鼠预防了高脂饮食诱导的体重增加、脂肪组织重塑和代谢紊乱。这些实验可能表明人类CRP和TACE在高脂饮食喂养下脂肪组织重塑和代谢紊乱的发病机制中的关键作用。

项目成果

Human C-reactive protein exacerbates metabolic disorders in association with adipose tissue remodeling

人类 C 反应蛋白加剧与脂肪组织重塑相关的代谢紊乱

• 发表时间: 2011
• 期刊: Cardiovasc Res
• 影响因子: 10.8
• 作者: Kaneko H;Anzai T;Nagai T;Anzai A;Takahashi T;Mano M;Morimoto K;Maekawa Y;Itoh H;Yoshikawa T;Ogawa S;Fukuda K
• 通讯作者: Fukuda K

Temporal Systemic Deletion of Tumor Necrosis Factor-α Converting Enzyme Prevents Development of High-Fat Diet-induced Insulin Resistance, Hepatosteatosis, Adipose Tissue Remodeling with Ameliorating Energy Expenditure

暂时性系统性删除肿瘤坏死因子-α 转换酶可防止高脂饮食引起的胰岛素抵抗、肝脂肪变性、脂肪组织重塑并改善能量消耗

• 发表时间: 2010
• 作者: Kaneko H;Anzai T;Horiuchi K;Morimoto K;Itoh H;Okada Yasunori;Yoshikawa T;Ogawa S;Fukuda K
• 通讯作者: Fukuda K

Tumor necrosis factor-〓 converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis

肿瘤坏死因子-〓转换酶失活改善高脂饮食诱导的胰岛素抵抗并改变能量稳态

• 发表时间: 2011
• 期刊: Circulation Journal
• 影响因子: 3.3
• 作者: Kaneko H;Anzai;T;Horiuchi;K;Morimoto K;Anzai A;Nagai T;Maekawa Y;Itoh H;Yoshikawa T;Okada Y;Ogawa S;Fukuda K;Hidehiro Kaneko;Hidehiro Kaneko;Hidehiro Kaneko
• 通讯作者: Hidehiro Kaneko

Human C-reactive protein exacerbates obesity induced insulin resistance and hepatosteatosis associated with adipose tissue remodeling

人类 C 反应蛋白加剧肥胖引起的胰岛素抵抗和与脂肪组织重塑相关的肝脂肪变性

• 发表时间: 2010
• 作者: Kaneko H;Anza i T;Takah ashi T;Morimoto K;Maekawa Y;Itoh H;Yoshikawa T;Ogawa S;Fukuda K
• 通讯作者: Fukuda K

Tumor necrosis factor-□ converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis

肿瘤坏死因子-□转换酶失活可改善高脂饮食诱导的胰岛素抵抗并改变能量稳态

• 发表时间: 2011
• 期刊: Circulation Journal
• 影响因子: 3.3
• 作者: Kaneko H;Anzai;T;Horiuchi;K;Morimoto K;Anzai A;Nagai T;Maekawa Y;Itoh H;Yoshikawa T;Okada Y;Ogawa S;Fukuda K;Hidehiro Kaneko;Hidehiro Kaneko
• 通讯作者: Hidehiro Kaneko