Development of new therapy of cardiovascular disease utilizing specificity of biologically active peptide hormones

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We recently published that ghrelin(an orexigenic peptide) administration was able to improve malignant arrhythmia-induced mortality in acute myocardial infarction. The present study demonstrated that one dose of ghrelin improves death rate in acute phase and also prevents cardiac remodeling in myocardial infarction. Furthermore, also demonstrated that endogenous ghrelin suppressed arrhythmia-induced death through inhibition of sympathetic nerve activity and activation of parasympathetic nerve activity in acute myocardial infarcti on. These findings suggest potential usefulness of ghrelin as a therapeutic agent in myocardial infarction.