Analysis of the maintenance mechanism of slit diaphragm, essential structure for glomerular filtration in kidney

我们分析了Par-aPKC极性复合物如何参与维持裂孔隔膜结构、负责肾小球滤过屏障的细胞间连接复合物以及下游信号传导途径。我们发现，狭缝隔膜组件迅速内吞和外吞和PAR-aPKC调节Nephrin的胞吐。这一结果揭示了裂膈的形成和维持机制，这是预防蛋白尿所必需的。

We analyzed how the Par-aPKC polarity complex is involved in the maintenance of slit diaphragm structure, the intercellular junctional complex responsible for the glomerular filtration barrier, and in the downstream signaling pathway. We found that slit diaphragm components are rapidly endocytosed and exocytosed and PAR-aPKC regulates exocytosis of Nephrin. This result unravels the mechanism of formation and maintenance of slit diaphragm, which is necessary for the prevention of proteinuria.