The role of regulatory B cells in lung fibrosis model

肺纤维化的发病机制尚不清楚。诱发肺纤维化前的B细胞耗竭大大加重了疾病症状。同样，基因B细胞缺陷的肺纤维化也明显更严重。MT小鼠与野生型小鼠的比较。野生型调节性B细胞的过继转移。MT小鼠在疾病开始前显著降低肺病理。太老鼠。相比之下，病理炎症期的B细胞耗竭可显著抑制疾病症状。因此，B细胞在肺纤维化的发展过程中具有重要的调节和致病作用。

Pathogenesis of pulmonary fibrosis remains unclear. B cell depletion before the induction of lung fibrosis substantially exacerbated disease symptoms. Similarly, pulmonary fibrosis was also significantly worse in genetically B cell-deficient. MT mice when compared with wild type mice. The adoptive transfer of wild type regulatory B cells into. MT mice before disease initiation significantly reduced pulmonary pathology in. MT mice. By contrast, B cell depletion during the inflammatory phase of pathology dramatically suppressed disease symptoms. Thus, B cells have important regulatory and pathogenic roles during the development of lung fibrosis.