The role of regulatory B cells in lung fibrosis model

调节性B细胞在肺纤维化模型中的作用

• 批准号: 22791061
• 负责人: HAMAGUCHI Yasuhito
• 金额: $ 2.66万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791061/
• 关键词: 制御性B細胞; 肺線維症1; 肺線維症

Pathogenesis of pulmonary fibrosis remains unclear. B cell depletion before the induction of lung fibrosis substantially exacerbated disease symptoms. Similarly, pulmonary fibrosis was also significantly worse in genetically B cell-deficient. MT mice when compared with wild type mice. The adoptive transfer of wild type regulatory B cells into. MT mice before disease initiation significantly reduced pulmonary pathology in. MT mice. By contrast, B cell depletion during the inflammatory phase of pathology dramatically suppressed disease symptoms. Thus, B cells have important regulatory and pathogenic roles during the development of lung fibrosis.

肺纤维化的发病机制尚不清楚。在诱导肺纤维化之前，B细胞耗竭实质上加重了疾病症状。同样，肺纤维化在遗传B细胞缺陷的患者中也明显更严重。MT小鼠与野生型小鼠相比。将野生型调节性B细胞过继转移到.疾病开始前MT小鼠的肺病理学显著降低。MT小鼠。相比之下，病理学炎症阶段期间的B细胞耗竭显著抑制疾病症状。因此，B细胞在肺纤维化的发展过程中具有重要的调节和致病作用。

项目成果

B cell shave a dual effect on pulmonary fibrosis in duced by bleomycin in a mouse model

B细胞对小鼠模型中博来霉素诱导的肺纤维化具有双重作用

• 发表时间: 2011
• 作者: Hamaguchi Y;Tedder TF;Fujimoto M:
• 通讯作者: Fujimoto M:

A dual role of B cells in bleomycin-induced murine pulmonary fibrosis model

B细胞在博来霉素诱导的小鼠肺纤维化模型中的双重作用

• 发表时间: 2011
• 作者: Hamaguchi Y;Matsushita T;Hasegawa M;Tedder TF;Takehara K;Fujimoto M;濱口儒人
• 通讯作者: 濱口儒人

A dual roleof B cells in bleomycin-induced murine pulmonary fibrosis model

B细胞在博来霉素诱导的小鼠肺纤维化模型中的双重作用

• 发表时间: 2011
• 作者: Hamaguchi Y;Matsushita T;Hasegawa M;Tedder TF;Takehara K;Fujimoto M
• 通讯作者: Fujimoto M