Genome-wide association study of schizophrenia in a Japanese population and follow-up study

突触支架蛋白MAGI 2与包括谷氨酸受体在内的多种功能分子相互作用，被认为与精神分裂症的认知障碍有关。在这项研究中，我们进行了MAGI 2在精神分裂症的关联分析，并评估了该基因对认知功能的影响。结果，两个多态性（rs2190665，rs4729938）显示与精神分裂症相关的提示性证据。此外，发现rs2190665与执行功能受损相关。

A synapse scaffolding protein, MAGI2, interacts with a variety of functional molecules including glutamate receptors and is presumed to be relevant to cognitive impairment in schizophrenia. In this study, we conducted an association analysis of MAGI2 in schizophrenia and evaluated an effect of this gene on cognitive function. As a result, two polymorphisms(rs2190665、rs4729938) showed suggestive evidence of association with schizophrenia. In addition, rs2190665 was found to be related to impairment of executive function.