Thought disorder in schizophrenia on functional MRI study

与自我和他人参照加工相关的神经活动的定位研究已经描述了内侧前额叶皮质(MPFC)、前扣带回皮质(ACC)和前脑岛中自我参照和他人参照的活动，以及楔前叶的他人参照和自我参照的活动。因此，我们使用功能磁共振成像(FMRI)来探索精神分裂症患者和正常对照组之间大脑活动的差异。正常对照组的前脑岛表现出更高的激活，这与自我反思有关，而精神分裂症患者表现出更高的楔前叶激活，这是一个与他人反思相关的区域，尽管他们正在思考自己答案的正确性。这些结果表明，精神分裂症患者可能不会认为自己是自我，而是他人，即使在需要他们反思自己的任务中也是如此。

Efforts to localize neural activity associated with self-and other-referential processing have described the activity in the medial prefrontal cortex(mPFC), the anterior cingulate cortex(ACC), and the anterior insula for self-versus other-referencing and activity in the precuneus for other-versus self-referencing. We therefore explored differences in brain activity between patients with schizophrenia and normal controls using functional magnetic resonance imaging(fMRI). Normal controls showed higher activation of the anterior insula, which is associated with self-reflection, whereas patients with schizophrenia showed higher activation of the precuneus, an area associated with other-reflection, even though they were contemplating the correctness of their own answers. These results indicate that patients with schizophrenia may perceive themselves not as self but as other, even during tasks requiring them to reflect on themselves.