Thought disorder in schizophrenia on functional MRI study

精神分裂症思维障碍的功能性MRI研究

• 批准号: 22791143
• 负责人: MATSUDA Tetsuya
• 金额: $ 2.58万
• 依托单位: Tamagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791143/
• 关键词: 統合失調症; fMRI; 思考障害; 自動処理; 大脳基底核; 自己認知; セルフリフレクション

Efforts to localize neural activity associated with self-and other-referential processing have described the activity in the medial prefrontal cortex(mPFC), the anterior cingulate cortex(ACC), and the anterior insula for self-versus other-referencing and activity in the precuneus for other-versus self-referencing. We therefore explored differences in brain activity between patients with schizophrenia and normal controls using functional magnetic resonance imaging(fMRI). Normal controls showed higher activation of the anterior insula, which is associated with self-reflection, whereas patients with schizophrenia showed higher activation of the precuneus, an area associated with other-reflection, even though they were contemplating the correctness of their own answers. These results indicate that patients with schizophrenia may perceive themselves not as self but as other, even during tasks requiring them to reflect on themselves.

定位与自我和他人参照加工相关的神经活动的努力已经描述了内侧前额叶皮层（mPFC），前扣带皮层（ACC）和前额叶的活动，用于自我与他人参照，以及楔前叶的活动，用于他人与自我参照。因此，我们利用功能性磁共振成像（fMRI）探讨了精神分裂症患者和正常对照者大脑活动的差异。正常对照组的大脑前叶激活程度较高，这与自我反思有关，而精神分裂症患者的楔前叶激活程度较高，这是一个与他人反思有关的区域，即使他们正在考虑自己答案的正确性。这些结果表明，精神分裂症患者可能认为自己不是自我，而是他人，即使在要求他们反思自己的任务中。

项目成果

Eye gaze during observation of static faces in deaf people.

• DOI: 10.1371/journal.pone.0016919
• 发表时间: 2011-02-16
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Watanabe K;Matsuda T;Nishioka T;Namatame M
• 通讯作者: Namatame M

統合失調症の意思決定障害

精神分裂症的决策障碍

• 发表时间: 2011
• 期刊: 日本生物学的精神医学会誌
• 作者: 松田哲也;伊藤岳人;鈴木春香;丸谷俊之;松島英介;小島卓也
• 通讯作者: 小島卓也