The effects of exercise on neuroimaging and psychopharmacological study in depression

我们研究了运动治疗抑郁症的药理机制。本研究包括12例在我校医院就诊的抑郁症患者和36例健康对照。运动8周后，抑郁症患者HAM-D、SDS评分显著降低。运动显著增加抑郁症患者的NOx(P&lt；0.05)和MHPG(P&lt；0.01)，但对BDNF、HVA、血生化、血压、体重指数和WEST无明显影响。我们只评估了一名抑郁症患者的MRI和SPECT。运动后患者的脑血流量有所改善。运动前BDNF、NOx、MHPG、HVA水平与抑郁症状的改善无相关性。运动显著降低HVA(P&lt；0.05)，而对照组BDNF、NOx、MHPG、血生化、血压、体重指数和WEST无明显变化。我们不能评估MRI和SPECT对健康对照的影响。

We examined the pharmacological mechanisms of exercise on depression. This study included 12 patients with depression in our university hospital and 36 healthy controls. Ham-D and SDS score were significantly decreased after 8-week exercise in the patients with depression. Exercise significantly increased NOx (P<0.05) and MHPG (P<0.01), but not BDNF, HVA, blood biochemical exam, blood pressure, body mass index and west in depression. We assessed MRI and SPECT only one patient with depression. The cerebral blood flow with the patient was improved after the exercise. There were no associations between improvement of depression and the levels of BDNF, NOx, MHPG, HVA in before exercise. Exercise significantly decreased HVA (P<0.05), but not BDNF, NOx, MHPG, blood biochemical exam, blood pressure, body mass index and west in control. We cannot assess MRI and SPECT on healthy control.